ArticleBritish journal of cancer2017
Leukocyte telomere length and renal cell carcinoma survival in two studies.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Leukocyte Telomere Length Variants Are Independently Associated with Survival of Patients with Colorectal Cancer.Cancers · 2026Article
- Leukocyte telomere length serves as the novel prognostic biomarker for the resectable NSCLC.Scientific reports · 2025Article
- 5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.JCO precision oncology · 2024Article
- Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023Review
- Telomere-related gene risk model for prognosis and drug treatment efficiency prediction in kidney cancer.Frontiers in immunology · 2022Article
- Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma.Cancers · 2021Article
- Telomere length is associated with HIV infection, methamphetamine use, inflammation, and comorbid disease risk.Drug and alcohol dependence · 2021Observational
- Shorter Treatment-Naïve Leukocyte Telomere Length is Associated with Poorer Overall Survival of Patients with Pancreatic Ductal Adenocarcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors.Cancers · 2020Article
- Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies.JAMA network open · 2020Article
- Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients.EBioMedicine · 2020Article
- Telomere Length in Renal Cell Carcinoma: The Jekyll and Hyde Biomarker of Ageing of the Kidney.Cancer management and research · 2020Review
- Prognostic value of leukocyte telomere length in renal cell carcinoma patients.American journal of cancer research · 2020Article
- Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma.Translational cancer research · 2019Article
- Telomere length and survival in primary cutaneous melanoma patients.Scientific reports · 2018Article
- Telomere Length and Lung Cancer Mortality among Heavy Smokers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Article
- Depressive symptoms and shorter survival in lung cancer: the role of leukocyte telomere length.Psychology & healthArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundLeukocyte telomere length (LTL) is a potential biomarker of cancer prognosis; however, evidence for renal cell carcinoma (RCC) is inconsistent.
methodsWe investigated LTL and RCC-specific survival among 684 cases from the US kidney cancer study (USKC) and 241 cases from the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO). Leukocyte telomere length was measured by quantitative polymerase chain reaction, and hazard ratios (HRs) and 95% confidence intervals (CIs) computed using multivariable Cox models.
resultsShort LTL was associated with poorer disease-specific survival in both USKC (lowest vs highest quartile: HR: 2.3, 95% CI: 1.2-4.4; P for trend=0.02) and PLCO (HR: 2.4, 95% CI: 1.0-5.4; P=0.04). Among USKC cases, the association was strongest for stage-I RCC (HR: 5.5, 95% CI: 1.6-19.0; P=0.006).
conclusionsOur findings suggest that shorter LTL is an independent marker of poor RCC prognosis, particularly for stage-I disease.
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