Evidence map›Paper›PMID 28742498›Full record

ArticleeLife2017

Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition.

Petra Fischer, Alek Pogosyan, Damian M Herz, Binith Cheeran, Alexander L Green, James Fitzgerald, Tipu Z Aziz, Jonathan Hyam, Simon Little, Thomas Foltynie and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. The Control of Movements via Motor Gamma Oscillations.Frontiers in human neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Petra FischerMedical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-5585-8977
Alek PogosyanMedical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
Damian M HerzMedical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.
Binith CheeranNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Alexander L GreenNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-7262-7297
James FitzgeraldNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Tipu Z AzizNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Jonathan HyamUnit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom.
Simon LittleUnit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom.
Thomas FoltynieUnit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom.
Patricia LimousinUnit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom.
Ludvic ZrinzoUnit of Functional Neurosurgery, Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology, London, United Kingdom.
Peter BrownMedical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5201-3044
Huiling TanMedical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-8038-3029

Funding

Medical Research Council MC_UU_12024/1Medical Research Council MR/P012272/1Wellcome TrustWellcome Trust 105804/Z/14/Z
6 · The paper itself

Abstract

Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson's disease patients. Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful stopping would occur only in ~50% of all trials. STN gamma (60-90 Hz) increased most strongly when the tap was successfully stopped, whereas phase-based connectivity between the contralateral STN and motor cortex decreased. Beta or theta power seemed less directly related to stopping. In summary, STN gamma activity may support flexible motor control as it did not only increase during movement execution but also during rapid action-stopping.

Indexed as

Gamma RhythmMotor ActivityAgedDeep Brain StimulationElectroencephalographyFemaleHumansMaleMiddle AgedParkinson DiseaseSubthalamic Nucleusbasal gangliafinger tappinghumanmotor inhibitionneuroscienceParkinson's diseasestoppingstop signal

Identifiers

PMID28742498
PMCPMC5526662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.