Evidence map›Paper›PMID 28742222›Full record

ArticleImmunology2017

Disruption of the ATP/adenosine balance in CD39

Amanda J Lanser, Rafael M Rezende, Stephen Rubino, Paul J Lorello, Dustin J Donnelly, Huixin Xu, Lauren A Lau, Chris G Dulla, Barbara J Caldarone, Simon C Robson and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Cannabidiol alleviates methamphetamine addictionActa pharmaceutica Sinica. B · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. CD39 Regulation and Functions in T Cells.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Review
  12. Targeting CD39 in cancer.Nature reviews. Immunology · 2020
    Review
  13. Article
  14. Review
  15. P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases.International journal of molecular sciences · 2020
    Review
  16. Article
  17. Novel Players in the Aging Synapse: Impact on Cognition.Journal of caffeine and adenosine research · 2019
    Review
  18. Review
  19. Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Amanda J LanserAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0953-495X
Rafael M RezendeAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Stephen RubinoAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Paul J LorelloNeuroBehavior Laboratory, Harvard NeuroDiscovery Center, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Dustin J DonnellyAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Huixin XuAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Lauren A LauDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Chris G DullaDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.
Barbara J CaldaroneNeuroBehavior Laboratory, Harvard NeuroDiscovery Center; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Simon C RobsonLiver Center and The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Howard L WeinerAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USTufts University · USBeth Israel Deaconess Medical Center · US

Funding

Impact of Astrocytic Glutamate Transport on Epilepsy Associated with DevelopmentaR01NS076885 · NINDS · TUFTS UNIVERSITY BOSTON · PI DULLA, CHRIS G · 2012 to 2016
$1.8M
NINDS NIH HHS R01 NS076885
6 · The paper itself

Abstract

Seizures are due to excessive, synchronous neuronal firing in the brain and are characteristic of epilepsy, the fourth most prevalent neurological disease. We report handling-induced and spontaneous seizures in mice deficient for CD39, a cell-surface ATPase highly expressed on microglial cells. CD39

Indexed as

AdenosineAdenosine TriphosphateAnimalsAntigens, CDApyraseCalcium-Binding ProteinsCerebral CortexHippocampusLipopolysaccharidesMiceMice, KnockoutMicrofilament ProteinsSeizuresAdenosineAdenosine TriphosphateAif1 protein, mouseAntigens, CDApyraseCalcium-Binding ProteinsCD39 antigenLipopolysaccharidesMicrofilament ProteinsadenosineATPCD39epilepsymicrogliaseizure

Identifiers

PMID28742222
PMCPMC5680053
OpenAlexW2737470304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.