ArticlePLoS pathogens2017
Salmonella enterica serovar-specific transcriptional reprogramming of infected cells.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Neutrophil prime unique transcriptional responses in intestinal organoids during infection with nontyphoidalmSphere · 2024Article
- Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway.PLoS pathogens · 2023Article
- The genomic and epidemiological virulence patterns of Salmonella enterica serovars in the United States.PloS one · 2023Article
- Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling.PLoS pathogens · 2022Article
- Complete Genome Sequence of Salmonella enterica Serovar Typhi Strain ISP2825.Microbiology resource announcements · 2021Article
- Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoids.PLoS pathogens · 2021Article
- Host restriction, pathogenesis and chronic carriage of typhoidal Salmonella.FEMS microbiology reviews · 2021Review
- New Insights on the Early Interaction Between Typhoid and Non-typhoidFrontiers in microbiology · 2021Review
- Essential role of Salmonella Enteritidis DNA adenine methylase in modulating inflammasome activation.BMC microbiology · 2020Article
- Complete genome sequence and annotation of the laboratory reference strain Shigella flexneri serotype 5a M90T and genome-wide transcriptional start site determination.BMC genomics · 2020Article
- Article
- Oxidation of phenylalanyl-tRNA synthetase positively regulates translational quality control.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- FeFrontiers in physiology · 2019Article
- Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever GroupFrontiers in cellular and infection microbiology · 2019Article
- Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10.Cell reports · 2018Article
- Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile.Infection and immunity · 2018Article
- World leprosy day 2018: How forward respecting the past?The Indian journal of medical research · 2018Article
- Iron oxide nanozyme suppresses intracellularTheranostics · 2018Article
- Activation of epigenetic regulator KDM6B byGut microbesArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Despite their high degree of genomic similarity, different Salmonella enterica serovars are often associated with very different clinical presentations. In humans, for example, the typhoidal S. enterica serovar Typhi causes typhoid fever, a life-threatening systemic disease. In contrast, the non-typhoidal S. enterica serovar Typhimurium causes self-limiting gastroenteritis. The molecular bases for these different clinical presentations are incompletely understood. The ability to re-program gene expression in host cells is an essential virulence factor for typhoidal and non-typhoidal S. enterica serovars. Here, we have compared the transcriptional profile of cultured epithelial cells infected with S. Typhimurium or S. Typhi. We found that both serovars stimulated distinct transcriptional responses in infected cells that are associated with the stimulation of specific signal transduction pathways. These specific responses were associated with the presence of a distinct repertoire of type III secretion effector proteins. These observations provide major insight into the molecular bases for potential differences in the pathogenic mechanisms of typhoidal and non-typhoidal S. enterica serovars.
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