ArticleTranslational psychiatry2017
Emergent, remitted and persistent psychosis-spectrum symptoms in 22q11.2 deletion syndrome.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Disentangling Psychopathology and Social Cognition in 22q11.2 Deletion Syndrome with Psychotic Symptoms and Schizophrenia.Schizophrenia bulletin open · 2026Article
- Sleep difficulties related to psychopathology and neurocognition in people with 22q11.2 deletion syndrome.Psychiatry research · 2025Article
- Neurocognitive functioning during adolescence: Spanish validation of the Penn Computerized Neurocognitive Battery.International journal of methods in psychiatric research · 2024Article
- Remote assessment of the Penn computerised neurocognitive battery in individuals with 22q11.2 deletion syndrome.Journal of intellectual disability research : JIDR · 2024Article
- Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.Molecular psychiatry · 2023Article
- Relationship between intelligence quotient measures and computerized neurocognitive performance in 22q11.2 deletion syndrome.Brain and behavior · 2021Article
- Inter-rater reliability of subthreshold psychotic symptoms in individuals with 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2021Article
- Neuroimaging Phenotypes Associated With Risk and Resilience for Psychosis and Autism Spectrum Disorders in 22q11.2 Microdeletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Early language measures associated with later psychosis features in 22q11.2 deletion syndrome.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- Neural and behavioral measures suggest that cognitive and affective functioning interactions mediate risk for psychosis-proneness symptoms in youth with chromosome 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2020Article
- Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology.Translational psychiatry · 2020Article
- The Medical Care of People With Intellectual Disability.Deutsches Arzteblatt international · 2019Review
- Abnormal development of early auditory processing in 22q11.2 Deletion Syndrome.Translational psychiatry · 2019Article
- Recent developments in understanding the relationship between 22q11.2 deletion syndrome and psychosis.Current opinion in psychiatry · 2019Review
- Olfactory deficits and psychosis-spectrum symptoms in 22q11.2 deletion syndrome.Schizophrenia research · 2018Article
- Childhood Executive Functioning Predicts Young Adult Outcomes in 22q11.2 Deletion Syndrome.Journal of the International Neuropsychological Society : JINS · 2018Article
- Longitudinal perspectives on the psychosis spectrum in 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2018Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals with 22q11.2 deletion syndrome (22q11DS) are at markedly elevated risk for schizophrenia-related disorders. Stability, emergence, remission and persistence of psychosis-spectrum symptoms were investigated longitudinally. Demographic, clinical and cognitive predictors of psychosis were assessed. Prospective follow-up over 2.8 years was undertaken in 75 individuals with 22q11DS aged 8-35 years. Mood, anxiety, attention-deficit hyperactivity disorders and psychosis-spectrum symptoms were assessed with the Kiddie-Schedule for Affective Disorders and Schizophrenia and Scale of Prodromal Symptoms (SOPS). Four domains of cognition were evaluated with the Penn Computerized Neurocognitive Battery (executive functioning, memory, complex cognition and social cognition). Psychotic disorder or clinically significant SOPS-positive ratings were consistently absent in 35%, emergent in 13%, remitted in 22% and persistent in 31% of participants. Negative symptoms and functional impairment were found to be predictive of the emergence of positive psychosis-spectrum symptoms and to reflect ongoing deficits after remission of positive symptoms. Dysphoric mood and anxiety were predictive of emergent and persistent-positive psychosis-spectrum symptoms. Lower baseline global cognition and greater global cognitive decline were predictive of psychosis-spectrum outcomes but no particular cognitive domain stood out as being significantly more discriminating than others. Our findings suggest that negative symptoms, functioning and dysphoric mood are important predictors of psychosis risk in this population.
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Registered trials
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