ArticleMicrobiology (Reading, England)2017
Bacterial communities in the small intestine respond differently to those in the caecum and colon in mice fed low- and high-fat diets.
Article in Microbiology (Reading, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Short-term high fat diet-induced metabolic endotoxemia in older individuals with obesity: a randomized crossover study.The American journal of clinical nutrition · 2025Trial
- Application of edible fungi in gut microbiota regulation.NPJ science of food · 2025Review
- Relationship between high-fat diet, gut microbiota, and precocious puberty: mechanisms and implications.Frontiers in microbiology · 2025Review
- Modulation of Gut Microbiome Community Mitigates Multiple Sclerosis in a Mouse Model: The Promising Role ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Immunomodulatory effect of marine lipids on food allergy.Frontiers in nutrition · 2023Review
- Omega-3 Fatty Acids and Their Interaction with the Gut Microbiome in the Prevention and Amelioration of Type-2 Diabetes.Nutrients · 2022Review
- The deficiency of FKBP-5 inhibited hepatocellular progression by increasing the infiltration of distinct immune cells and inhibiting obesity-associated gut microbial metabolite.Journal of gastrointestinal oncology · 2021Article
- Characteristics of the gut microbiome profile in obese patients with colorectal cancer.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity.Mediators of inflammation · 2021Review
- Individual and Site-Specific Variation in a Biogeographical Profile of the Coyote Gastrointestinal Microbiota.Microbial ecology · 2021Article
- Host miRNA-21 promotes liver dysfunction by targeting small intestinalGut microbes · 2020Article
- Review
- Impact of intestinal parasites on microbiota and cobalamin gene sequences: a pilot study.Parasites & vectors · 2020Article
- Microbiota changes in a pediatric acute lymphocytic leukemia mouse model.MicrobiologyOpen · 2020Article
- Raw milk and fecal microbiota of commercial Alpine dairy cows varies with herd, fat content and diet.PloS one · 2020Article
- Microbial Profiles of Cirrhosis in the Human Small Intestine.Current gastroenterology reports · 2019Review
- Genetic determinants of gut microbiota composition and bile acid profiles in mice.PLoS genetics · 2019Article
- Effects of Different Diets on Microbiota in The Small Intestine Mucus and Weight Regulation in Rats.Scientific reports · 2019Article
- Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine.Scientific reports · 2019Article
- Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans.mSphere · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial communities in the mouse caecum and faeces are known to be altered by changes in dietary fat. The microbiota of the mouse small intestine, by contrast, has not been extensively profiled and it is unclear whether small intestinal bacterial communities shift with dietary fat levels. We compared the microbiota in the small intestine, caecum and colon in mice fed a low-fat (LF) or high-fat (HF) diet using 16S rRNA gene sequencing. The relative abundance of major phyla in the small intestine, Bacteriodetes, Firmicutes and Proteobacteria, was similar to that in the caecum and colon; the relative abundance of Verrucomicrobia was significantly reduced in the small intestine compared to the large intestine. Several genera were uniquely detected in the small intestine and included the aerotolerant anaerobe, Lactobacillus spp. The most abundant genera in the small intestine were accounted for by anaerobic bacteria and were identical to those identified in the large intestine. An HF diet was associated with significant weight gain and adiposity and with changes in the bacterial communities throughout the intestine, with changes in the small intestine differing from those in the caecum and colon. Prominent Gram-negative bacteria including genera of the phylum Bacteroidetes and a genus of Proteobacteria significantly changed in the large intestine. The mechanistic links between these changes and the development of obesity, perhaps involving metabolic endotoxemia, remain to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.