Evidence map›Paper›PMID 28741855›Full record

ArticleStem cells (Dayton, Ohio)2017

In Vivo Rescue of the Hematopoietic Niche By Pluripotent Stem Cell Complementation of Defective Osteoblast Compartments.

Rhiannon Chubb, James Oh, Alyssa K Riley, Takaharu Kimura, Sean M Wu, Joy Y Wu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells (Dayton, Ohio), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026
    Review
  2. Article
  3. Osteoblast Lineage Support of Hematopoiesis in Health and Disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Review
  4. Article
  5. International journal of stem cells · 2022
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rhiannon ChubbEndocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
James OhEndocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Alyssa K RileyCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Takaharu KimuraDivision of Endocrinology, Stanford University School of Medicine, Stanford, California, USA.
Sean M WuCardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Joy Y WuEndocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1897-4503
Massachusetts General Hospital · USStanford Medicine · US

Funding

Enabling Technologies for Human-Machine Hybrid TissuesDP1LM012179 · NLM · STANFORD UNIVERSITY · PI WU, SEAN M · 2014 to 2018
$3.8M
Generation of functional organs via developmental chimerismDP2OD004411 · OD · STANFORD UNIVERSITY · PI WU, SEAN M · 2008 to 2008
$2.5M
"In vivo reconstitution of the hematopoietic niche"DP2OD008466 · OD · STANFORD UNIVERSITY · PI WU, JOY Y · 2011 to 2011
$2.4M
NIH HHS DP2 OD004411NIH HHS DP2 OD008466NLM NIH HHS DP1 LM012179
6 · The paper itself

Abstract

Bone-forming osteoblasts play critical roles in supporting bone marrow hematopoiesis. Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSC), are capable of differentiating into osteoblasts. To determine the capacity of stem cells needed to rescue aberrant skeletal development and bone marrow hematopoiesis in vivo, we used a skeletal complementation model. Mice deficient in Runx2, a master transcription factor for osteoblastogenesis, fail to form a mineralized skeleton and bone marrow. Wild-type (WT) green fluorescent protein (GFP)

Indexed as

Cell DifferentiationHumansOsteoblastsOsteogenesisPluripotent Stem CellsStem Cell NicheBone formationHematopoietic nicheOsteoblastPluripotent stem cell

Identifiers

PMID28741855
PMCPMC5610643
OpenAlexW2737206645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.