ReviewJournal of endocrinological investigation2018
Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms.
Review in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05275608 (Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients with Metabolic Syndrome
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE).Journal of endocrinological investigation · 2019Pooled it
- Cold induces increased ad libitum energy intake independent of changes in energy expenditure: a controlled crossover trial in adults.The American journal of clinical nutrition · 2025Trial
- Adaptive thermogenesis after moderate weight loss: magnitude and methodological issues.European journal of nutrition · 2022Trial
- Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype.The American journal of clinical nutrition · 2021Trial
- Specific metabolic rate and body weight regulation: racial and ethnic differences in mass-independent energy expenditure.Journal of endocrinological investigation · 2026Article
- Obesity: a disease of the ponderostat and the regulation of energy balance.Eating and weight disorders : EWD · 2025Review
- Sex-specific metabolic responses to high-fat diet in mice with NOX4 deficiency.Redox biology · 2025Article
- Papillary Thyroid Carcinoma and Body Mass Index: The Role of Immune System in Tumor Microenvironment.International journal of molecular sciences · 2025Article
- Experiences of Wheelchair Users With Spinal Cord Injury With Self-Tracking and Commercial Self-Tracking Technology ("In Our World, Calories Are Very Important"): Qualitative Interview Study.JMIR human factors · 2025Article
- Parsing reward sensitivity reveals distinct relationships with energy intake, metabolic markers, physical activity and fitness.Acta neuropsychiatrica · 2025Article
- Energy metabolism and obesity stratified by BMI: impact on lipid oxidation, a cross-sectional observational study.Frontiers in nutrition · 2025Article
- Adverse Childhood Experiences and Risk of Abnormal Body Mass Index: A Global Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2024Review
- Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans.International journal of obesity (2005) · 2024Article
- Secular trends and determinants ofFrontiers in nutrition · 2024Article
- Greater anhedonia scores in healthy individuals are associated with less decline in 24-hour energy expenditure with fasting: Evidence for a link between behavioral traits and spendthrift phenotype.Physiology & behavior · 2023Article
- A Study on the Amelioration of Circadian Rhythm Disorders in Fat Mice Using High-Protein Diets.Nutrients · 2023Article
- The Influence of Energy Balance and Availability on Resting Metabolic Rate: Implications for Assessment and Future Research Directions.Sports medicine (Auckland, N.Z.) · 2023Review
- Association of adverse childhood experiences (ACEs) with obesity and underweight in children.Eating and weight disorders : EWD · 2022Article
- Review
- The counterbalancing effects of energy expenditure on body weight regulation: Orexigenic versus energy-consuming mechanisms.Obesity (Silver Spring, Md.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance may lead to weight gain; however, results from different study groups are contradictory and indicate a complex interaction between EE and food intake which may differentially influence weight change in humans. Recently, studies evaluating the adaptive response of one component to perturbations of the other component of energy balance have revealed both the existence of differing metabolic phenotypes ("spendthrift" and "thrifty") resulting from overeating or underfeeding, as well as energy-sensing mechanisms linking EE to food intake, which might explain the propensity of an individual to weight gain. The purpose of this review is to debate the role that human EE plays on body weight regulation and to discuss the physiologic mechanisms linking EE and food intake. An increased understanding of the complex interplay between human metabolism and food consumption may provide insight into pathophysiologic mechanisms underlying weight gain, which may eventually lead to prevention and better treatment of human obesity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.