Evidence map›Paper›PMID 28741141›Full record

ArticleProtoplasma2018

Detonation nanodiamonds are promising nontoxic delivery system for urothelial cells.

Daša Zupančič, Mateja Erdani Kreft, Maja Grdadolnik, Dimitar Mitev, Aleš Iglič, Peter Veranič

Abstract read
PubMed Publisher
In one paragraph

Article in Protoplasma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Daša ZupančičInstitute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia. dasa.zupancic@mf.uni-lj.si.ORCID http://orcid.org/0000-0001-9492-5706
Mateja Erdani KreftInstitute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.
Maja GrdadolnikInstitute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.
Dimitar MitevREGPOT-2012-2013-1 NMP INERA Project, Institute of Solid State Physics-BAS, 72 Tzarigradsko Chaussee Blvd, 1784, Sofia, Bulgaria.
Aleš IgličLaboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, 1000, Ljubljana, Slovenia.
Peter VeraničInstitute of Cell Biology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, Slovenia.
University of Ljubljana · SIGeorgi Nadjakov Institute of Solid State Physics · BG

Funding

Javna Agencija za Raziskovalno Dejavnost RS J3-7494Javna Agencija za Raziskovalno Dejavnost RS P2-0232Javna Agencija za Raziskovalno Dejavnost RS P3-0108
6 · The paper itself

Abstract

Detonation nanodiamonds (DNDs) are carbon-based nanomaterials that are among the most promising nanoparticles available for biomedical applications so far. This is due to their biocompatibility, which could be contributed to their inert core and conformable surface nature. However, DNDs cytotoxicity for urothelial cells and the routes of their internalization remains an open question in the aspect of nanodiamond surface. We therefore analyzed four types of DNDs for cytotoxicity and internalization with normal urothelial cells and two types of cancer urothelial cell lines in vitro. Viability of any of the cell types we used was not compromised with any of four DNDs we evaluated after 24-, 48- and 72-h incubation in three different concentrations of DNDs. Transmission electron microscopy revealed that all four types of DNDs were endocytosed into all three types of urothelial cells tested here. We observed DNDs in endosomes, as well as in multivesicular bodies and multilamellar bodies. These results propose using of DNDs as a delivery system for urological applications in human nanomedicine.

Indexed as

HumansMicroscopy, Electron, TransmissionNanodiamondsUrotheliumNanodiamondsCytotoxicityDelivery systemDetonation nanodiamondsInternalizationTransmission electron microscopyUrothelial cells

Identifiers

PMID28741141
OpenAlexW2739443088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.