Evidence map›Paper›PMID 28741126›Full record

ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2017

An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers.

Nisha Rao, Henry A Spiller, Nichole L Michaels, Thiphalak Chounthirath, Marcel J Casavant, Amrit K Kamboj, Gary A Smith

Open access · bronzeAbstract read
In one paragraph

Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 44 citations in OpenAlex.

  1. Insights into dietary supplements as popular product supporting the diet.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  2. Review
  3. Pediatric Exposures Associated with Caffeine Energy Products Reported to United States Poison Centers, 2011-2023.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025
    Article
  4. Toxicity Potential of Nutraceuticals.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Impact of Energy Drinks on Health and Well-being.Current nutrition reports · 2018
    Review
  12. Comment on "An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers".Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2018
    Article
  13. Author response to Kingston's comment on "An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers".Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2018
    Article
  14. Article
  15. Patients' perceptions and use of natural health products.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Nisha RaoCenter for Injury Research and Policy of the Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Henry A SpillerThe Ohio State University College of Medicine, Columbus, OH, USA.
Nichole L MichaelsCenter for Injury Research and Policy of the Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Thiphalak ChounthirathCenter for Injury Research and Policy of the Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Marcel J CasavantCenter for Injury Research and Policy of the Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Amrit K KambojCenter for Injury Research and Policy of the Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Gary A SmithCenter for Injury Research and Policy of the Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. gary.smith@nationwidechildrens.org.
The Ohio State University · USMayo Clinic in Florida · USNationwide Children's Hospital · USNationwide Mutual Insurance Company (United States) · USWashington Poison Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe objective of this study was to investigate the epidemiology of dietary supplement exposures in the USA.

methodsA retrospective analysis was conducted of out-of-hospital dietary supplement exposures reported to the National Poison Data System from 2000 through 2012.

resultsThere were 274,998 dietary supplement exposures from 2000 through 2012. The annual rate of dietary supplement exposures per 100,000 population increased by 46.1% during 2000-2002, decreased 8.8% during 2002-2005, and then increased again by 49.3% from 2005 to 2012. These trends were influenced by the decrease in ma huang exposures starting in 2002. Miscellaneous dietary supplements accounted for 43.9% of all exposures, followed by botanicals (31.9%), hormonal products (15.1%), and other supplements (5.1%). The majority of dietary supplement exposures (70.0%) occurred among children younger than 6 years old and were acute (94.0%) and unintentional (82.9%). Serious medical outcomes accounted for 4.5% of exposures and most (95.0%) occurred among individuals 6 years and older. Ma huang products, yohimbe, and energy products were the categories associated with the greatest toxicity.

conclusionsThere was an overall increase in the rate of dietary supplement exposures from 2000 through 2012. Although the majority of these exposures did not require treatment at a health care facility or result in serious medical outcomes, exposures to yohimbe and energy products were associated with considerable toxicity. Our results demonstrate the success of the FDA ban on ma huang products and the need for FDA regulation of yohimbe and energy products in the USA.

Indexed as

AdolescentAdultChildChild, PreschoolDatabases, FactualDietary SupplementsDrugs, Chinese HerbalEnergy DrinksEphedraEphedra sinicaFemaleHumansInfantMaleMiddle AgedPlant PreparationsDrugs, Chinese HerbalEphedrae herbaPlant PreparationsYohimbineDietary supplementEnergy productsMa huangPoison control centerYohimbe

Identifiers

PMID28741126
PMCPMC5570731
OpenAlexW2738634599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.