ArticleClinical rheumatology2018
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry.
Article in Clinical rheumatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Vaccines for preventing herpes zoster in older adults.The Cochrane database of systematic reviews · 2023Pooled it
- Vaccines for preventing herpes zoster in older adults.The Cochrane database of systematic reviews · 2019Pooled it
- Review
- Incidence of autoimmune disease after hernia surgery with a mesh implant: national retrospective cohort study.The British journal of surgery · 2026Article
- Shoenfeld syndrome or Autoimmune/Inflammatory Syndrome Induced by Adjuvants syndrome: a case of inguinal hernia mesh rejection after 9 years.Journal of surgical case reports · 2026Article
- Autoimmune/Inflammatory Syndrome Induced by Adjuvants With Sarcoid-Like Pulmonary Lesions Triggered by Silicone Implant Rupture and Improved After Explantation.Respirology case reports · 2026Article
- An Atypical Presentation of Thyroid Eye Disease in a Patient With a Remote History of Graves' Disease.Cureus · 2025Article
- The Occurrence of Health Symptoms in General Practice Before and After the Explantation of Cosmetic Breast Implants.Aesthetic surgery journal · 2025Article
- Symptoms of ASIA Syndrome in a Female Patient with Tattoos - A Case Report.Clinical, cosmetic and investigational dermatology · 2025Article
- Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) After Polypropylene Mesh Implantation - Protocol of a Pilot Study for Diagnostics and Treatment.Journal of abdominal wall surgery : JAWS · 2025Article
- Clinical Characteristics of ASIA Syndrome in Patients with Silicone Breast Implants: A Scoping Review.World journal of plastic surgery · 2025Review
- Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): A case of systemic symptoms following breast implants and vaccinations.International journal of surgery case reports · 2024Article
- Vaccines and the Eye: Current Understanding of the Molecular and Immunological Effects of Vaccination on the Eye.International journal of molecular sciences · 2024Review
- Palpitation in women with silicone breast implants: association with autoantibodies against autonomic nervous system.Immunologic research · 2024Article
- Autoimmune Autoinflammatory Syndrome Induced by Adjuvants (ASIA) After Injection of Foreign Materials for Cosmetic Purposes: Retrospective Analysis of 1027 Cases.Aesthetic plastic surgery · 2024Article
- Uveal effusion syndrome following COVID-19 vaccination.American journal of ophthalmology case reports · 2023Article
- Article
- Panniculitis as a manifestation of metal-associated autoimmune/inflammatory syndrome induced by adjuvants: a case-based review.Rheumatology international · 2023Review
- Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications.Clinical and experimental immunology · 2023Review
- Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a recently identified condition in which the exposure to an adjuvant leads to an aberrant autoimmune response. We aimed to summarize the results obtained from the ASIA syndrome registry up to December 2016, in a descriptive analysis of 300 cases of ASIA syndrome, with a focus on the adjuvants, the clinical manifestations, and the relationship with other autoimmune diseases. A Web-based registry, based on a multicenter international study, collected clinical and laboratory data in a form of a questionnaire applied to patients with ASIA syndrome. Experts in the disease validated all cases independently. A comparison study regarding type of adjuvants and differences in clinical and laboratory findings was performed. Three hundred patients were analyzed. The mean age at disease onset was 37 years, and the mean duration of time latency between adjuvant stimuli and development of autoimmune conditions was 16.8 months, ranging between 3 days to 5 years. Arthralgia, myalgia, and chronic fatigue were the most frequently reported symptoms. Eighty-nine percent of patients were also diagnosed with another defined rheumatic/autoimmune condition. The most frequent autoimmune disease related to ASIA syndrome was undifferentiated connective tissue disease (UCTD). ASIA syndrome is associated with a high incidence of UCTD and positive anti-nuclear antibodies (ANA) test. Clinical and laboratory features differ from the type of adjuvant used. These findings may contribute to an increased awareness of ASIA syndrome and help physicians to identify patients at a greater risk of autoimmune diseases following the exposure to vaccines and other adjuvants. The ASIA syndrome registry provides a useful tool to systematize this rare condition.
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