ArticleBrain structure & function2018
Shifted dynamic interactions between subcortical nuclei and inferior frontal gyri during response preparation in persistent developmental stuttering.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- A Proof-of-Concept Study of Gamified Rhythmic Training in Preadolescents Who Stutter.Annals of the New York Academy of Sciences · 2026Trial
- The Effects of tDCS on Speech Fluency in People Who Stutter: A Narrative Review.The European journal of neuroscience · 2025Review
- Article
- Article
- An fMRI study of initiation and inhibition of manual and spoken responses in people who stutter.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Evidence for planning and motor subtypes of stuttering based on resting state functional connectivity.Brain and language · 2024Article
- Speaking to a metronome reduces kinematic variability in typical speakers and people who stutter.PloS one · 2024Article
- Dissecting structural connectivity of the left and right inferior frontal cortex in children who stutter.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- White matter tract strength correlates with therapy outcome in persistent developmental stuttering.Human brain mapping · 2022Article
- The Role of Basal Ganglia and Its Neuronal Connections in the Development of Stuttering: A Review Article.Cureus · 2022Review
- Atypical development of Broca's area in a large family with inherited stuttering.Brain : a journal of neurology · 2022Article
- Behavioral and neural correlates of speech motor sequence learning in stuttering and neurotypical speakers: an fMRI investigation.Neurobiology of language (Cambridge, Mass.) · 2021Article
- Performance of Bimanual Finger Coordination Tasks in Speakers Who Stutter.Frontiers in psychology · 2021Article
- Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter.Frontiers in human neuroscience · 2021Article
- Functional and Neuroanatomical Bases of Developmental Stuttering: Current Insights.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Methylphenidate and stuttering.British journal of clinical pharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Persistent developmental stuttering is associated with basal ganglia dysfunction or dopamine dysregulation. Here, we studied whole-brain functional connectivity to test how basal ganglia structures coordinate and reorganize sensorimotor brain networks in stuttering. To this end, adults who stutter and fluent speakers (control participants) performed a response anticipation paradigm in the MRI scanner. The preparation of a manual Go/No-Go response reliably produced activity in the basal ganglia and thalamus and particularly in the substantia nigra. Strikingly, in adults who stutter, substantia nigra activity correlated positively with stuttering severity. Furthermore, functional connectivity analyses yielded altered task-related network formations in adults who stutter compared to fluent speakers. Specifically, in adults who stutter, the globus pallidus and the thalamus showed increased network synchronization with the inferior frontal gyrus. This implies dynamic shifts in the response preparation-related network organization through the basal ganglia in the context of a non-speech motor task in stuttering. Here we discuss current findings in the traditional framework of how D1 and D2 receptor activity shapes focused movement selection, thereby suggesting a disproportional involvement of the direct and the indirect pathway in stuttering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.