Evidence map›Paper›PMID 28740773›Full record

ArticlePlastic and reconstructive surgery. Global open2017

Botulinum Toxin A as an Adjunct to Abdominal Wall Reconstruction for Incisional Hernia.

Sinor Soltanizadeh, Frederik Helgstrand, Lars N Jorgensen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04143776 (Renal- and Pulmonary Function in Relation to Abdominal Hypertension After Abdominal Reconstruction), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04143776 withdrawnnot on this mapstarted 2020, after this paper: background citation

Renal- and Pulmonary Function in Relation to Abdominal Hypertension After Abdominal Reconstruction: The REPARE-study

TypeobservationalSponsorBispebjerg HospitalRan2020 to 2020Enrolled0ConditionsHernia, Ventral, Hernia Incisional, Acute Kidney Injury, Restrictive Lung DiseaseArmsAbdominal reconstruction
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. A structured pathway for developing your complex abdominal hernia service: our York pathway.Hernia : the journal of hernias and abdominal wall surgery · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Sinor SoltanizadehDigestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen NV, Denmark; and Department of Surgery, Zealand University Hospital, Køge, Denmark.
Frederik HelgstrandDigestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen NV, Denmark; and Department of Surgery, Zealand University Hospital, Køge, Denmark.
Lars N JorgensenDigestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen NV, Denmark; and Department of Surgery, Zealand University Hospital, Køge, Denmark.
Bispebjerg Hospital · DKUniversity of Copenhagen · DKZealand University Hospital Køge · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRepair of large incisional hernias remains a surgical and costly challenge. Temporary paralysis of the lateral abdominal wall muscles with topical administration of botulinum toxin A (BTA) is a new therapeutic concept, which may obviate the need for component separation technique (CST) for repair of large incisional hernias. Current literature on the administration of BTA as adjunct to surgical repair of abdominal incisional hernias was investigated.

methodsThe electronic databases PubMed and Embase were searched for eligible studies. Two independent investigators evaluated the literature. Data were sought regarding primary fascial closure with and without CST, safety, hernia recurrence, method of application, and preoperative radiological imaging.

resultsSix cohort studies including a total of 133 patients receiving BTA were identified. No randomized or case-control studies were found. In total, 83.5% of the patients achieved primary fascial closure. Supplemental CST was necessary in 24.1% of the patients. Two patients developed hernia recurrence during follow-up. No postoperative complications or adverse events were considered related to the administration of BTA, except for impairment of postoperative coughing and sneezing. Additionally, radiological imaging showed that BTA increased the length of lateral abdominal muscles before surgery.

conclusionsPreoperative administration of BTA increases muscle length and may facilitate primary fascial closure. Optimal administration is at least 2 weeks before repair, whereas the optimal dose of BTA remains to be defined. Carefully designed randomized controlled trials are warranted to identify patients who would benefit from BTA and to eliminate the confounding effect of CST.

Identifiers

PMID28740773
PMCPMC5505834
OpenAlexW2653806871

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.