Evidence map›Paper›PMID 28740749›Full record

ArticlePeerJ2017

A longitudinal study of the diabetic skin and wound microbiome.

Melissa Gardiner, Mauro Vicaretti, Jill Sparks, Sunaina Bansal, Stephen Bush, Michael Liu, Aaron Darling, Elizabeth Harry, Catherine M Burke

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06310239 (Osseointegrated Limb Implant Microbiome Population Adaptation Study), which is not on this map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06310239 recruitingnot on this mapstarted 2023, after this paper: background citation

Osseointegrated Limb Implant Microbiome Population Adaptation Study

Typeobservational_patient_registrySponsorWalter Reed National Military Medical CenterRan2023 to 2029Enrolled50ConditionsAmputation With OsseointegrationArmsCollection of biologic samples and data
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 147 citations in OpenAlex.

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  8. The contribution of probiotics to combined cellular therapy in skin wound healing in diabetic rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025
    Article
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  20. Direct metagenomics investigation of non-surgical hard-to-heal wounds: a review.Annals of clinical microbiology and antimicrobials · 2024
    Review

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Melissa GardinerThe i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
Mauro VicarettiMedical School, University of Sydney, Sydney, New South Wales, Australia.
Jill SparksCommunity Nursing, Western Sydney Local Health District, Sydney, New South Wales, Australia.
Sunaina BansalThe i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
Stephen BushSchool of Mathematical and Physical Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.
Michael LiuThe i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
Aaron DarlingThe i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
Elizabeth HarryThe i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
Catherine M BurkeThe i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
University of Technology Sydney · AUSydney Local Health District · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType II diabetes is a chronic health condition which is associated with skin conditions including chronic foot ulcers and an increased incidence of skin infections. The skin microbiome is thought to play important roles in skin defence and immune functioning. Diabetes affects the skin environment, and this may perturb skin microbiome with possible implications for skin infections and wound healing. This study examines the skin and wound microbiome in type II diabetes.

methodsEight type II diabetic subjects with chronic foot ulcers were followed over a time course of 10 weeks, sampling from both foot skin (swabs) and wounds (swabs and debrided tissue) every two weeks. A control group of eight control subjects was also followed over 10 weeks, and skin swabs collected from the foot skin every two weeks. Samples were processed for DNA and subject to 16S rRNA gene PCR and sequencing of the V4 region.

resultsThe diabetic skin microbiome was significantly less diverse than control skin. Community composition was also significantly different between diabetic and control skin, however the most abundant taxa were similar between groups, with differences driven by very low abundant members of the skin communities. Chronic wounds tended to be dominated by the most abundant skin DISCUSSION: The major difference observed in this study of the skin microbiome associated with diabetes was a significant reduction in diversity. The long-term effects of reduced diversity are not yet well understood, but are often associated with disease conditions.

Indexed as

16S rRNA gene sequencingDiabetesDiabetic ulcerDiversitySkin microbiome

Identifiers

PMID28740749
PMCPMC5522608
OpenAlexW2739082771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.