ArticleClinical psychological science : a journal of the Association for Psychological Science2017
Hippocampal volume as an amplifier of the effect of social context on adolescent depression.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Hippocampal Volume Moderates the Link between Racial-Ethnic Discrimination and Early Adolescent Depression.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Depression in Chinese adolescents: prevalence, symptoms, risk factors, affected brain, diagnosis, and interventions.Frontiers in psychology · 2026Review
- Identifying neural mediators and cultural moderators of the association between discrimination and depression among Mexican American youth.Scientific reports · 2025Article
- The moderating role of hippocampal volume in the association between emotional abuse and peer victimization in adolescents with major depressive disorder.European child & adolescent psychiatry · 2025Article
- Environmental and neurodevelopmental contributors to youth mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Early life stress predicts trajectories of emotional problems and hippocampal volume in adolescence.European child & adolescent psychiatry · 2024Article
- A short-interval longitudinal study of associations between psychological distress and hippocampal grey matter in early adolescence.Brain imaging and behavior · 2024Article
- Observed Parenting and Adolescent Brain Structure.Developmental neuropsychology · 2023Article
- The longitudinal role of family conflict and neural reward sensitivity in youth's internalizing symptoms.Social cognitive and affective neuroscience · 2023Article
- Prenatal programming of environmental sensitivity.Translational psychiatry · 2023Review
- Psychosocial Predictors of Suicidal Thoughts and Behaviors in Mexican-Origin Youths: An 8-Year Prospective Cohort Study.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Heart rate variability moderates the effects of COVID-19-related stress and family adversity on emotional problems in adolescents: Testing models of differential susceptibility and diathesis stress.Development and psychopathology · 2022Article
- Racial discrimination associates with lower cingulate cortex thickness in trauma-exposed black women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- The role of educational attainment and brain morphology in major depressive disorder: Findings from the ENIGMA major depressive disorder consortium.Journal of psychopathology and clinical science · 2022Article
- Early experience unpredictability in child development as a model for understanding the impact of the COVID-19 pandemic: A translational neuroscience perspective.Developmental cognitive neuroscience · 2022Article
- Hippocampal volume indexes neurobiological sensitivity to the effect of pollution burden on telomere length in adolescents.New directions for child and adolescent development · 2022Article
- Neonatal hippocampal volume moderates the effects of early postnatal enrichment on cognitive development.Developmental cognitive neuroscience · 2020Article
- Neonatal brain volume as a marker of differential susceptibility to parenting quality and its association with neurodevelopment across early childhood.Developmental cognitive neuroscience · 2020Article
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6 authors.
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Abstract
Recent models have focused on how brain-based individual differences in social sensitivity shape affective development in adolescence, when rates of depression escalate. Given the importance of the hippocampus in binding contextual and affective elements of experience, as well as its putative role in depression, we examined hippocampal volume as a moderator of the effects of social context on depressive symptoms in a sample of 209 Mexican-origin adolescents. Adolescents with larger versus smaller hippocampal volumes showed heightened sensitivity in their depressive symptoms to a protective factor inside the home (sense of family connectedness) and a risk factor outside of it (community crime exposure). These interactive effects uniquely predicted depressive symptoms and were greater for the left side, suggesting two independent social-contextual contributions to depression that were moderated by left hippocampal volume. Results elucidate complex brain-environment interplay in adolescent depression, offering clues about for whom and how social context plays a role.
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