ReviewNeural plasticity2017
Environmental Factors Promoting Neural Plasticity: Insights from Animal and Human Studies.
Review in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03978052 (Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention), which is not on this map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic Review and Transcriptomic Meta-analysis of Environmental Enrichment Reveal Core Molecular Programs of Brain Plasticity.Molecular neurobiology · 2026Pooled it
- The impact of different exercise types on cognitive function in patients with multiple sclerosis: a systematic review and network meta-analysis.Journal of neurology · 2025Pooled it
- Global research on 24-hour movement behaviours guidelines in children and adolescents: a systematic review.The international journal of behavioral nutrition and physical activity · 2025Pooled it
- Childhood Material Hardship Linked to Adolescent Neurocognition: A Computational Modeling Approach.Developmental science · 2026Article
- Science Is About Thinking: How Can We Protect Thinking Time in a Distracted Digital World?Brain sciences · 2026Review
- Longitudinal and Bidirectional Relationships Between Sleep, Emotional Wellbeing and Weight Status in Childhood and Adolescence: Growing Up in Scotland Cohort Analysis.Journal of sleep research · 2026Article
- Beyond Adversity: Definitions, Retrospective Assessment, and Experimental Manipulation of Positive Early-Life Experiences.Brain sciences · 2026Review
- Sensory Deprivation and the Brain: Neurobiological Mechanisms, Psychological Effects, and Clinical Implications.Brain sciences · 2026Review
- Dysregulation of Immune Mediators and Synaptic Plasticity in Central Nervous System Disorders.Cells · 2026Review
- Environmental enrichment accelerates the stabilization of cortical representation duringiScience · 2026Article
- Drivers and mechanisms of cognitive decline in chronic kidney disease.Nature reviews. Nephrology · 2025Review
- Expatriates' Cultural Intelligence Mediates the Relationship Between Lifestyle and Performance: A Cross-Sectional Analysis and a Longitudinal Pilot Study.Brain and behavior · 2025Article
- Experimental modeling of Alzheimer's disease: Translational lessons from cross-taxon analyses.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Can an active lifestyle maintain cognitive efficiency in older adults? A pilot study of the relationship between physical activity and graphic fluency.BMC psychology · 2025Article
- Exploring the Correlation Between Sleep Chronotype and the Volumes of Subcortical Structures and Hippocampal Subfields in Young Healthy Population.Brain sciences · 2025Article
- Hallmarks of Brain Plasticity.Biomedicines · 2025Review
- Home Environment as a Therapeutic Target for Prevention and Treatment of Chronic Diseases: Delivering Restorative Living Spaces, Patient Education and Self-Care by Bridging Biophilic Design, E-Commerce and Digital Health Technologies.International journal of environmental research and public health · 2025Article
- The Transition From Homogeneous to Heterogeneous Machine Learning in Neuropsychiatric Research.Biological psychiatry global open science · 2025Review
- Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1.Frontiers in systems neuroscience · 2025Article
- Probiotic supplementation prevents stress-impaired spatial learning and enhances the effects of environmental enrichment.Frontiers in microbiomes · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We do not all grow older in the same way. Some individuals have a cognitive decline earlier and faster than others who are older in years but cerebrally younger. This is particularly easy to verify in people who have maintained regular physical activity and healthy and cognitively stimulating lifestyle and even in the clinical field. There are patients with advanced neurodegeneration, such as Alzheimer's disease (AD), that, despite this, have mild cognitive impairment. What determines this interindividual difference? Certainly, it cannot be the result of only genetic factors. We are made in a certain manner and what we do acts on our brain. In fact, our genetic basis can be modulated, modified, and changed by our experiences such as education and life events; daily, by sleep schedules and habits; or also by dietary elements. And this can be seen as true even if our experiences are indirectly driven by our genetic basis. In this paper, we will review some current scientific research on how our experiences are able to modulate the structural organization of the brain and how a healthy lifestyle (regular physical activity, correct sleep hygiene, and healthy diet) appears to positively affect cognitive reserve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.