ArticleJournal of thoracic disease2017
The value of positive lymph nodes ratio combined with negative lymph node count in prediction of breast cancer survival.
Article in Journal of thoracic disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association of a high versus low number of negative lymph nodes removed with survival and recurrence-free survival after lymph node dissection in breast cancer: a systematic review and meta-analysis of observational studies.Clinical and experimental medicine · 2025Pooled it
- Predicting breast cancer-specific survival in metaplastic breast cancer patients using machine learning algorithms.Journal of pathology informatics · 2023Article
- Prognostic Factors and a Model for Occult Breast Cancer: A Population-Based Cohort Study.Journal of clinical medicine · 2022Article
- Prognostic Nomogram for Postoperative Hypopharyngeal Squamous Cell Carcinoma to Assist Decision Making for Adjuvant Chemotherapy.Journal of clinical medicine · 2022Article
- Breast Cancer Patients With Positive Apical or Infraclavicular/Ipsilateral Supraclavicular Lymph Nodes Should Be Excluded in the Application of the Lymph Node Ratio System.Frontiers in cell and developmental biology · 2022Article
- The prognostic value of lymph node ratio in comparison to positive lymph node count in penile squamous cell carcinoma.International urology and nephrology · 2021Article
- Impact of the extent of negative lymph nodes in gastric adenocarcinoma undergoing primary surgical resection: An institutional report.Journal of the Chinese Medical Association : JCMA · 2021Article
- Predictive Value of Pretreatment Peripheral Neutrophil-to-Lymphocyte Ratio for Response to Neoadjuvant Chemotherapy and Breast Cancer Prognosis.Cancer management and research · 2021Article
- Negative lymph node count is an independent prognostic factor for female patients with node positive breast cancer.Translational cancer research · 2020Article
- Frequency and Association Of GSTM1 and GSTT1 Gene Polymorphisms with Survival in Breast Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Clinical significance of tumor necrosis factor receptor 2 in middle and lower thoracic esophageal squamous cell carcinoma.Oncology letters · 2018Article
- SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis.BMC gastroenterology · 2018Article
- Positive relationship between number of negative lymph nodes and duration of gallbladder cancer cause-specific survival after surgery.Cancer management and research · 2018Article
- Clinical, Histopathological, and Immunohistochemical Characteristics of Predictive Biomarkers of Breast Cancer: A Retrospective Study.Cancer diagnosis & prognosisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPositive lymph node ratio (LNR), defined as ratio of positive lymph nodes to all lymph nodes removed, is a powerful prognostic factor in invasive breast cancer. Here we focused on the impact of negative lymph node (NLN) count on the prediction of value of LNR in breast cancer survival.
methodsOf 929 invasive breast cancer patients were enrolled in our retrospective study. We use Kaplan-Meier to calculate the 5-year overall survival (OS) according to different clinicopathologic parameters. The prediction value of NLN count and LNR in OS was examined.
resultsThe optimal cutoff of NLN count was designated as 9. Five-year OS was 77.0% and 95.0% in patients with NLN of 0-9 and ≥10, respectively (P<0.001). Among 204 patients who had 0-9 NLN, 25 patients with LNR 0-20.0% had 5-year OS of 95.7%, 104 patients with LNR 20.1-65.0% had 5-year OS of 83.4%, and 75 patients with LNR 65.1-100.0% had 5-year OS of 61.7% (P<0.001); Among 725 patients who had NLN ≥10, 650 patients with LNR 0-20.0% had 5-year OS of 96.1%, 68 patients with LNR 20.1-65.0% had 5-year OS of 86.8%, and 7 patients with LNR 65.1-100% had 5-year OS of 71.4% (P<0.001).
conclusionsHigh NLN count is associated with improved survival in invasive breast cancer patients. Combining NLN count with LNR could be considered as an alternative to LNR alone in prediction of postoperative breast cancer survival.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.