Evidence map›Paper›PMID 28740576›Full record

ArticleGenes & cancer2017

The chemokine scavenging receptor D6/ACKR2 is a target of miR-146a in thyroid cancer.

Francesco Pacifico, Alessio Lepore, Stefano Mellone, Luca Sanguigno, Giorgia Federico, Adelaide Greco, Arturo Brunetti, Antonio Leonardi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. NF-κB in Thyroid Cancer: An Update.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francesco PacificoIstituto di Endocrinologia e Oncologia Sperimentale, CNR, Naples, Italy.
Alessio LeporeDipartimento di Medicina Molecolare e Biotecnologie Mediche, Federico II University, Naples, Italy.
Stefano MelloneIstituto di Endocrinologia e Oncologia Sperimentale, CNR, Naples, Italy.
Luca SanguignoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Federico II University, Naples, Italy.
Giorgia FedericoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Federico II University, Naples, Italy.
Adelaide GrecoDipartimento di Scienze Biomediche Avanzate, Federico II University, Naples, Italy.
Arturo BrunettiDipartimento di Scienze Biomediche Avanzate, Federico II University, Naples, Italy.
Antonio LeonardiDipartimento di Medicina Molecolare e Biotecnologie Mediche, Federico II University, Naples, Italy.
Ceinge Biotecnologie Avanzate (Italy) · ITInstitute for Experimental Endocrinology and Oncology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that miR-146a, a NF-κB-regulated microRNA, is strongly expressed in human specimens and cell lines derived from anaplastic thyroid carcinomas (ATC) where it mediates some of the NF-κB pro-tumorigenic functions. By using a bioinformatic analysis, we identified the chemokine scavenger receptor D6/ ACKR2 as a target of miR146a in human ATC. We found that the expression of D6/ ACKR2 was up-regulated in miR-146a-null ATC cell lines and that the 3' UTR of D6/ ACKR2 mRNA was able to inhibit its expression in parental, but not in miR-146a-null ATC cells. Since human specimens from primary ATC showed a low expression of D6/ ACKR2 compared to normal thyroid tissues, we analyzed the effects of D6/ACKR2 over-expression in ATC cells. Different chemokines added to the conditioned medium of D6/ACKR2 over-expressing ATC cells partially failed to drive

Indexed as

chemokinesD6/ACKR2 receptormiR-146aNF-κBthyroid cancer

Identifiers

PMID28740576
PMCPMC5511891
OpenAlexW3022249935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.