Evidence map›Paper›PMID 28740553›Full record

ArticleTheranostics2017

A Fluorogenic Probe for Ultrafast and Reversible Detection of Formaldehyde in Neurovascular Tissues.

Xing-Guang Liang, Bo Chen, Ling-Xiao Shao, Juan Cheng, Ming-Zhu Huang, Yu Chen, Yong-Zhou Hu, Yi-Feng Han, Feng Han, Xin Li

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Theranostics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xing-Guang LiangCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Bo ChenDepartment of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Ling-Xiao ShaoCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Juan ChengCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Ming-Zhu HuangCentral Laboratory, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Yu ChenCentral Laboratory, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Yong-Zhou HuCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yi-Feng HanDepartment of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Feng HanCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Xin LiCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhejiang University · CNZhejiang Sci-Tech University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formaldehyde (FA) is endogenously produced in live systems and has been implicated in a diverse array of pathophysiological processes. To disentangle the detailed molecular mechanisms of FA biology, a reliable method for monitoring FA changes in live cells would be indispensable. Although there have been several fluorescent probes reported to detect FA, most are limited by the slow detection kinetics and the intrinsic disadvantage of detecting FA in an irreversible manner which may disturb endogenous FA homeostasis. Herein we developed a coumarin-hydrazonate based fluorogenic probe (

Indexed as

Alzheimer DiseaseAnimalsCerebral CortexCoumarinsDisease Models, AnimalFluorescent DyesFormaldehydeHippocampusHydrazonesMiceOptical ImagingSensitivity and SpecificityCoumarinsFluorescent DyesFormaldehydeHydrazonesfluorescent probeformaldehydeneurodegenerative disorderneurovascular cell.

Identifiers

PMID28740553
PMCPMC5505062
OpenAlexW2622886147

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.