ArticleFrontiers in plant science2017
Multi-Omics and Integrated Network Analyses Reveal New Insights into the Systems Relationships between Metabolites, Structural Genes, and Transcriptional Regulators in Developing Grape Berries (
Article in Frontiers in plant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Grape Berry Secondary Metabolites and Their Modulation by Abiotic Factors in a Climate Change Scenario-A Review.Frontiers in plant science · 2021Pooled it
- Network aggregation improves gene function prediction of grapevine gene co-expression networks.Plant molecular biology · 2020Pooled it
- A Metabolome Atlas of Grape Biodiversity.Journal of agricultural and food chemistry · 2026Article
- Highly dynamic metabolic response of grapevine to water deficits reveals an adaptability to a wide range of climatic conditions.Food chemistry: X · 2026Article
- Fine scale gene expression dynamics at the foliar level reveal grapevine strategies to cope with recurrent drought stress.BMC plant biology · 2026Article
- Anatomical Changes in the Peel of Sun-Damaged Pomegranates (Plants (Basel, Switzerland) · 2026Article
- Study of Intact Glycosidic Aroma Precursors in Recovered Minority White Grape Varieties under Water Stress Conditions.Journal of agricultural and food chemistry · 2026Article
- Molecular and physiological mechanisms of drought tolerance in grapevine.Frontiers in plant science · 2026Review
- Differences in Non-Anthocyanin Phenolics and Antioxidant Capacity of 27 Red Grapevine Varieties Grown in Northern Portugal.Molecules (Basel, Switzerland) · 2025Article
- Genomic resources and genetic improvement of vital tropical and subtropical fruit crops: current status and prospects.AoB PLANTS · 2025Review
- Toward understanding grapevine responses to climate change: a multi-stress and holistic approach.Journal of experimental botany · 2025Review
- Adaptation to Climate Change in Viticulture: The Role of Varietal Selection-A Review.Plants (Basel, Switzerland) · 2025Review
- The scion-driven transcriptomic changes guide the resilience of grafted near-isohydric grapevines under water deficit.Horticulture research · 2025Article
- Novel Targets for Fruit Conservation Strategies Revealed by Omics Studies: A Systematic Review and Meta-Analysis.International journal of food science · 2025Review
- Appropriate mowing can promote the growth of Anabasis aphylla through the auxin metabolism pathway.BMC plant biology · 2024Article
- NAC61 regulates late- and post-ripening osmotic, oxidative, and biotic stress responses in grapevine.Journal of experimental botany · 2024Article
- Berry shrivel in grapevine: a review considering multiple approaches.Journal of experimental botany · 2024Review
- Integrated volatile metabolome and transcriptome analyses provide insights into the warm aroma formation elicited by methyl jasmonate in carrot root.Frontiers in plant science · 2024Article
- High-Resolution Mass Spectrometry-Based Metabolomics for Increased Grape Juice Metabolite Coverage.Foods (Basel, Switzerland) · 2023Article
- MYB24 orchestrates terpene and flavonol metabolism as light responses to anthocyanin depletion in variegated grape berries.The Plant cell · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grapes are one of the major fruit crops and they are cultivated in many dry environments. This study comprehensively characterizes the metabolic response of grape berries exposed to water deficit at different developmental stages. Increases of proline, branched-chain amino acids, phenylpropanoids, anthocyanins, and free volatile organic compounds have been previously observed in grape berries exposed to water deficit. Integrating RNA-sequencing analysis of the transcriptome with large-scale analysis of central and specialized metabolites, we reveal that these increases occur via a coordinated regulation of key structural pathway genes. Water deficit-induced up-regulation of flavonoid genes is also coordinated with the down-regulation of many stilbene synthases and a consistent decrease in stilbenoid concentration. Water deficit activated both ABA-dependent and ABA-independent signal transduction pathways by modulating the expression of several transcription factors. Gene-gene and gene-metabolite network analyses showed that water deficit-responsive transcription factors such as bZIPs, AP2/ERFs, MYBs, and NACs are implicated in the regulation of stress-responsive metabolites. Enrichment of known and novel
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.