ArticleFrontiers in endocrinology2017
Both Low Blood Glucose and Insufficient Treatment Confer Risk of Neurodevelopmental Impairment in Congenital Hyperinsulinism: A Multinational Cohort Study.
Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Latitudinal differences on the global epidemiology of infantile spasms: systematic review and meta-analysis.Orphanet journal of rare diseases · 2018Pooled it
- [Clinical practice guidelines "Congenital hyperinsulinism"].Problemy endokrinologii · 2026Review
- Knowledge, attitudes, and practices in pediatric hypoglycemia in Italy (KAPPHy study).Journal of endocrinological investigation · 2026Article
- Real-world insights into neurodevelopmental outcomes amongst people with congenital hyperinsulinism.Orphanet journal of rare diseases · 2026Article
- Umbilical Cord Blood Glucose Concentrations and Transitional Neonatal Hypoglycemia.JAMA network open · 2026Article
- Advances in Pharmacotherapy for Congenital Hyperinsulinism.Paediatric drugs · 2026Review
- Single-center experience description of surgical management of diffuse congenital hyperinsulinism in a pediatric non-current cohort.Frontiers in endocrinology · 2026Article
- Expanding the phenotype of CARS1 variants to include congenital hyperinsulinism.BMC medical genomics · 2025Article
- Severe transient neonatal hyperinsulinism: First Peruvian case series.SAGE open medical case reports · 2025Article
- Genotype-histotype-phenotype correlations in hyperinsulinemic hypoglycemia.Histology and histopathology · 2024Review
- Transitional Neonatal Hypoglycemia and Adverse Neurodevelopment in Midchildhood.JAMA network open · 2024Article
- Congenital hyperinsulinism in the Ukraine: a 10-year national study.Frontiers in endocrinology · 2024Article
- Case Report: The importance of genetic counseling for families with hyperinsulinism.Frontiers in pediatrics · 2024Article
- [Electroencephalogram features in children with congenital hyperinsulinism treated according to the international protocol in Russian Federation].Problemy endokrinologii · 2023Article
- Hyperinsulinemic Hypoglycemia Diagnosed in Childhood Can Be Monogenic.The Journal of clinical endocrinology and metabolism · 2023Article
- Accuracy and impact on quality of life of real-time continuous glucose monitoring in children with hyperinsulinaemic hypoglycaemia.Frontiers in endocrinology · 2023Article
- Neonatal hypoglycemia: lack of evidence for a safe management.Frontiers in endocrinology · 2023Review
- Article
- Hyperinsulinemic Hypoglycemia Associated with a CaInternational journal of molecular sciences · 2022Article
- Light on the horizon? Will Continuous Glucose Monitoring Allow for Better Management of Congenital Hyperinsulinism?The Journal of clinical endocrinology and metabolism · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsCongenital hyperinsulinism (CHI) is a heterogeneous disease most frequently caused by KATP-channel (ABCC8 and KCNJ11) mutations, with neonatal or later onset, variable severity, and with focal or diffuse pancreatic involvement as the two major histological types. CHI confers a high risk of neurological impairment; however, sparsely studied in larger patient series. We assessed the neurodevelopmental outcome in children with CHI at follow-up in a mixed international cohort.
methodsIn two hyperinsulinism expert centers, 75 CHI patients were included (Russian,
resultsMedian (range) age at follow-up was 3.7 years (3.3 months-18.2 years). Neurodevelopmental impairment was seen in 35 (47%). Impairment was associated with abnormal brain magnetic resonance imaging (MRI); odds ratio (OR) (95% CI) 15.0 (3.0-74.3),
conclusionNot only very low blood glucose, but also insufficient treatment as expressed by delay until expert center hospitalization, increased the risk of neurodevelopmental impairment. This novel finding calls for improvements in spread of knowledge about CHI among health-care personnel and rapid contact with an expert CHI center on suspicion of CHI.
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