Evidence map›Paper›PMID 28740450›Full record

ArticleRadiology and oncology2017

Single Nucleotide Polymorphisms in Genes

Matej Horvat, Uros Potocnik, Katja Repnik, Rajko Kavalar, Vesna Zadnik, Stojan Potrc, Borut Stabuc

Open access · goldAbstract read
In one paragraph

Article in Radiology and oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. The impacts ofJournal of Cancer · 2023
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  7. Effects ofJournal of Cancer · 2020
    Article
  8. The Contribution ofCancer genomics & proteomics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Matej HorvatDepartment of Oncology, University Medical Centre Maribor, Maribor, Slovenia.
Uros PotocnikCentre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Katja RepnikCentre for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Rajko KavalarDepartment of Pathology, University Medical Centre Maribor, Maribor, Slovenia.
Vesna ZadnikEpidemiology and Cancer Registry, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
Stojan PotrcDepartment of General and Abdominal Surgery, University Medical Centre Maribor, Maribor, Slovenia.
Borut StabucDepartment of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
University Clinical Centre Maribor · SIUniversity of Maribor · SIInstitute of Oncology Ljubljana · SILjubljana University Medical Centre · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) represents one of the most common malignancies worldwide. Research has indicated that functional gene changes such as single nucleotide polymorphism (SNP) influence carcinogenesis and metastasis and might have an influence on disease relapse. The aim of our study was to evaluate the role of SNPs in selected genes as prognostic markers in resectable CRC. PATIENTS AND

methodsIn total, 163 consecutive patients treated surgically for CRC of stages I, II and III at the University Medical Centre in Maribor in 2007 and 2008 were investigated. DNA was isolated from formalin-fixed paraffin-embedded CRC tissue from the Department of Pathology and SNPs in genes

resultsWe found worse disease-free survival (DFS) for patients with TT genotype of SNP rs1990172 in gene

conclusionsOur results indicate the role of SNPs as prognostic factors in resectable CRC.

Indexed as

colorectal cancerMACC1MMP7RAD18SDF-1asingle nucleotide polymorphism

Identifiers

PMID28740450
PMCPMC5514655
OpenAlexW2510446416

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.