Evidence map›Paper›PMID 28740446›Full record

ArticleRadiology and oncology2017

Diffusion Kurtosis Imaging of Gliomas Grades II and III - A Study of Perilesional Tumor Infiltration, Tumor Grades and Subtypes at Clinical Presentation.

Anna F Delgado, Markus Fahlström, Markus Nilsson, Shala G Berntsson, Maria Zetterling, Sylwia Libard, Irina Alafuzoff, Danielle van Westen, Jimmy Lätt, Anja Smits and 1 more

Abstract read
In one paragraph

Article in Radiology and oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna F DelgadoDepartment of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Markus FahlströmDepartment of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.
Markus NilssonBioimaging Center, Lund University, Lund, Sweden.
Shala G BerntssonDepartment of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
Maria ZetterlingDepartment of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden.
Sylwia LibardDepartment of Immunology, Genetics and Pathology, Section of pathology, Uppsala University Hospital and Uppsala University, Uppsala, Sweden.
Irina AlafuzoffDepartment of Immunology, Genetics and Pathology, Section of pathology, Uppsala University Hospital and Uppsala University, Uppsala, Sweden.
Danielle van WestenClinical Sciences Lund, Diagnostic Radiology, Lund University, Lund, Sweden.
Jimmy LättDepartment of Imaging and Function, Skåne University Healthcare, Lund, Sweden.
Anja SmitsDepartment of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
Elna-Marie LarssonDepartment of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiffusion kurtosis imaging (DKI) allows for assessment of diffusion influenced by microcellular structures. We analyzed DKI in suspected low-grade gliomas prior to histopathological diagnosis. The aim was to investigate if diffusion parameters in the perilesional normal-appearing white matter (NAWM) differed from contralesional white matter, and to investigate differences between glioma malignancy grades II and III and glioma subtypes (astrocytomas and oligodendrogliomas). PATIENTS AND

methodsForty-eight patients with suspected low-grade glioma were prospectively recruited to this institutional review board-approved study and investigated with preoperative DKI at 3T after written informed consent. Patients with histologically proven glioma grades II or III were further analyzed (n=35). Regions of interest (ROIs) were delineated on T2FLAIR images and co-registered to diffusion MRI parameter maps. Mean DKI data were compared between perilesional and contralesional NAWM (student's

resultsThere were significant differences in all mean DKI variables between perilesional and contralesional NAWM (

conclusionsMean DKI variables in perilesional NAWM differ significantly from contralesional NAWM, suggesting altered microstructure by tumor infiltration not depicted on morphological MRI. Histogram analysis of DKI data identifies differences between glioma grades and subtypes.

Indexed as

diffusion kurtosis imaging (DKI)gliomagradeperilesionalsubtypetumor infiltration

Identifiers

PMID28740446
PMCPMC5514651

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.