ReviewDiabetes, metabolic syndrome and obesity : targets and therapy2017
Prevalence of diabetes and obesity in association with prematurity and growth restriction.
Review in Diabetes, metabolic syndrome and obesity : targets and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies.PLoS medicine · 2023Pooled it
- Predicting the outcomes of preterm neonates beyond the neonatal intensive care unit: What are we missing?Pediatric research · 2021Pooled it
- Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction.Nutrients · 2024Article
- Pituitary gland height evaluated with magnetic resonance imaging in premature twins: the impact of growth and sex.Pediatric radiology · 2024Article
- Dietary diversity and other predictors of low birth weight in Gurage Zone, Ethiopia: Prospective study.PloS one · 2024Article
- Maternal Protein Restriction Inhibits Insulin Signaling and Insulin Resistance in the Skeletal Muscle of Young Adult Rats.Juntendo Iji zasshi = Juntendo medical journal · 2024Article
- Prematurity and BPD: what general pediatricians should know.European journal of pediatrics · 2023Review
- Odds of Cardiometabolic Diseases and Medications in Children With Cerebral Palsy.Journal of child neurology · 2023Observational
- Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats.Scientific reports · 2023Article
- Article
- Insulin resistance parameters in children born very preterm and adequate for gestational age.Endocrinology, diabetes & metabolism · 2022Article
- A Mixture of Endocrine Disrupting Chemicals Associated with Lower Birth Weight in Children Induces Adipogenesis and DNA Methylation Changes in Human Mesenchymal Stem Cells.International journal of molecular sciences · 2022Article
- A Matter of Fat: Body Fat Distribution and Cardiometabolic Disease in Africa.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Infant processed food consumption and their interaction to breastfeeding and growth in children up to six months old.BMC public health · 2021Article
- Maternal investment, life-history trajectory of the off-spring and cardiovascular disease risk in Emirati females in the United Arab Emirates.BMC public health · 2021Article
- Obesity, Early Life Gut Microbiota, and Antibiotics.Microorganisms · 2021Review
- Care of Infants Born to Women with Diabetes.Current diabetes reports · 2020Review
- [Effect of breastfeeding on insulin sensitivity in infants with intrauterine growth retardation: a follow-up study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Article
- Plasma Adipokines Profile in Prepubertal Children with a History of Prematurity or Extrauterine Growth Restriction.Nutrients · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrauterine growth restriction (IUGR) is when fetuses and newborn infants have not reached their true growth potential as genetically defined. Fetuses with IUGR develop in a less than ideal environment that leads to epigenetic changes and marks infants' metabolism for the rest of their lives. Epigenetic changes affect insulin-like growth factor-1 (IGF-1) levels and lead to insulin resistance and ultimately to a metabolic syndrome. The metabolic syndrome is a constellation of illnesses that raise one's risk for type 2 diabetes mellitus, coronary artery disease, and ischemic heart disease, including hypertension, dyslipidemia, central obesity, insulin resistance, and inflammation. The association between IUGR or prematurity and long-term insulin resistance, obesity, hypertension, and metabolic syndrome remains unclear. While studies have shown an association, others have not supported such association. If alteration of intrauterine growth can ultimately lead to the development of metabolic derangements in childhood and adulthood, and if such association is true, then early interventions targeting the health of pregnant women will ensure the health of the population to follow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.