ArticleScientific reports2017
Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Transcranial current stimulation in epilepsy: A systematic review of the fundamental and clinical aspects.Frontiers in neuroscience · 2022Pooled it
- Non-vectorial integration of intersectional short-pulse stimulation enables enhanced deep brain modulation and effective seizure control.Communications medicine · 2026Article
- Passive neuromodulation: an energy-driven mechanism for closed-loop suppression of epileptic seizures.bioRxiv : the preprint server for biology · 2026Article
- Manipulation of neuronal activity by an artificial spiking neural network implemented on a closed-loop brain-computer interface in non-human primates.Journal of neural engineering · 2025Article
- A Comprehensive Overview of the Current Status and Advancements in Various Treatment Strategies against Epilepsy.ACS pharmacology & translational science · 2024Review
- Microstimulation-based path tracking control of pigeon robots through parameter adaptive strategy.Heliyon · 2024Article
- Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures.Brain : a journal of neurology · 2023Article
- A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management.Brain sciences · 2023Review
- Closed-loop brain stimulation augments fear extinction in male rats.Nature communications · 2023Article
- Suppression of seizure in childhood absence epilepsy using robust control of deep brain stimulation: a simulation study.Scientific reports · 2023Article
- Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially.Nature communications · 2022Article
- Review
- Article
- Novel Non-invasive Transcranial Electrical Stimulation for Parkinson's Disease.Frontiers in aging neuroscience · 2022Review
- Recent advances in recording and modulation technologies for next-generation neural interfaces.iScience · 2021Review
- Dual-model wearable photoacoustic microscopy and electroencephalograph: study of neurovascular coupling in anesthetized and freely moving rats.Biomedical optics express · 2021Article
- State-space optimal feedback control of optogenetically driven neural activity.Journal of neural engineering · 2021Article
- The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies.Frontiers in neural circuits · 2021Review
- Temporally Targeted Interactions With Pathologic Oscillations as Therapeutical Targets in Epilepsy and Beyond.Frontiers in neural circuits · 2021Review
- Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review.Bioelectricity · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Closed-loop brain stimulation is a promising alternative to treat drug-resistant epilepsies. In contrast to optogenetic interventions, transcranial electrical stimulation (TES) does not require cellular modification of neurons to be effective, and it is less invasive compared to deep brain stimulation. Furthermore, on-demand TES of targeted brain regions allows the potential for normal function of these networks during interictal periods, a possibility that is eliminated by resective surgical treatment approaches. To further explore the translation of closed-loop TES for treatment of epilepsy, we show here for the first time that unsupervised closed-loop TES in rats can consistently interrupt seizures for 6 weeks and has the potential to control seizure activity up to 4 months (longest periods examined). On-demand TES significantly reduced the time spent in seizure and the individual seizure duration, although significantly higher seizure rate was observed during the treatment. The 6 week long stimulation had no residual adverse effects on the electrophysiologic characteristics of the brain after the termination of the treatment and did not induce glial remodelling in the brain. Our findings demonstrate the safety and effectiveness of minimally invasive, potentially lifelong TES treatment of epilepsy either alone or as a complement to drug treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.