ArticleScientific reports2017
Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Optimized phenotyping of complex morphological traits: enhancing discovery of common and rare genetic variants.Briefings in bioinformatics · 2025Article
- Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease risk.bioRxiv : the preprint server for biology · 2025Article
- A test of the ArchaicEvolution, medicine, and public health · 2025Article
- Enrichment of a subset of Neanderthal polymorphisms in autistic probands and siblings.Molecular psychiatry · 2024Article
- A Comprehensive Analysis of 3 Moroccan Genomes Revealed Contributions From Both African and European Ancestries.Evolutionary bioinformatics online · 2024Article
- How Well Do We Understand Autistic Savant Artists: A Review of Various Hypotheses and Research Findings to Date.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2023Article
- Effector-selective modulation of the effective connectivity within frontoparietal circuits during visuomotor tasks.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Echoes of ancient DNA in living modern humans affect risk for neuropsychiatric disease and brain structure and function of networks subserving higher-order cognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Merging morphological and genetic evidence to assess hybridization in Western Eurasian late Pleistocene hominins.Nature ecology & evolution · 2022Article
- Neanderthal-derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- The Superior Visual Perception Hypothesis: Neuroaesthetics of Cave Art.Behavioral sciences (Basel, Switzerland) · 2021Article
- Article
- Williams syndrome hemideletion and LIMK1 variation both affect dorsal stream functional connectivity.Brain : a journal of neurology · 2019Article
- Hybridization in human evolution: Insights from other organisms.Evolutionary anthropology · 2019Review
- Neanderthal clues to brain evolution in humans.Nature · 2019Article
- Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity.Current biology : CB · 2019Article
- Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes.Genes · 2018Review
- Primary visual cortex in neandertals as revealed from the occipital remains from the El Sidrón site, with emphasis on the new SD-2300 specimen.Journal of anatomy · 2018Article
- The evolution of modern human brain shape.Science advances · 2018Article
- PANDORA'S BOX.BJPsych international · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Before their disappearance from the fossil record approximately 40,000 years ago, Neanderthals, the ancient hominin lineage most closely related to modern humans, interbred with ancestors of present-day humans. The legacy of this gene flow persists through Neanderthal-derived variants that survive in modern human DNA; however, the neural implications of this inheritance are uncertain. Here, using MRI in a large cohort of healthy individuals of European-descent, we show that the amount of Neanderthal-originating polymorphism carried in living humans is related to cranial and brain morphology. First, as a validation of our approach, we demonstrate that a greater load of Neanderthal-derived genetic variants (higher "NeanderScore") is associated with skull shapes resembling those of known Neanderthal cranial remains, particularly in occipital and parietal bones. Next, we demonstrate convergent NeanderScore-related findings in the brain (measured by gray- and white-matter volume, sulcal depth, and gyrification index) that localize to the visual cortex and intraparietal sulcus. This work provides insights into ancestral human neurobiology and suggests that Neanderthal-derived genetic variation is neurologically functional in the contemporary population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.