ArticleScientific reports2017
Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- The atorvastatin metabolic phenotype shift is influenced by interaction of drug-transporter polymorphisms in Mexican population: results of a randomized trial.Scientific reports · 2020Trial
- Exploring the early drivers of pain in Parkinson's disease.Scientific reports · 2025Article
- Addressing the Ethnicity Gap in Catechol O-Methyl Transferase Inhibitor Trials in Parkinson's Disease: A Review of Available Global Data.Journal of personalized medicine · 2024Article
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- Integrated multiplexed assays of variant effect reveal determinants of catechol-O-methyltransferase gene expression.Molecular systems biology · 2024Article
- Shared Genetic Regulatory Networks Contribute to Neuropathic and Inflammatory Pain: Multi-Omics Systems Analysis.Biomolecules · 2022Article
- From saliva to SNP: non-invasive, point-of-care genotyping for precision medicine applications using recombinase polymerase amplification and giant magnetoresistive nanosensors.Lab on a chip · 2022Article
- The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome.Journal of personalized medicine · 2022Article
- Genotypes of Pain and Analgesia in a Randomized Trial of Irritable Bowel Syndrome.Frontiers in psychiatry · 2022Article
- Altered Neural Network Connectivity Predicts Depression inFrontiers in neuroscience · 2022Article
- Inhibition of catechol-Journal of enzyme inhibition and medicinal chemistry · 2021Article
- Analytical methodologies for sensing catechol-Journal of pharmaceutical analysis · 2021Review
- Polymorphisms in the HTR2A and HTR3A Genes Contribute to Pain in TMD Myalgia.Frontiers in oral health · 2021Article
- An Exploratory Analysis of the Association Between Catechol-O-Methyltransferase and Response to a Randomized Open-Label Placebo Treatment for Cancer-Related Fatigue.Frontiers in psychiatry · 2021Article
- Effects of caffeic acid on epigenetics in the brain of rats with chronic unpredictable mild stress.Molecular medicine reports · 2020Article
- Effects of safinamide on pain in Parkinson's disease with motor fluctuations: an exploratory study.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Nonmotor symptoms of 820 Taiwanese patients with Parkinson's disease: an exploratory-comparative study.Journal of neurology · 2020Article
- Depression Comorbid With Stroke, Traumatic Brain Injury, Parkinson's Disease, and Multiple Sclerosis: Diagnosis and Treatment.Focus (American Psychiatric Publishing) · 2020Article
- An overview of pain in Parkinson's disease.Clinical parkinsonism & related disorders · 2020Article
- The Association Analysis ofFrontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King's PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and rs4680 of COMT, rs6746030 of SCN9A, and rs1799971 of OPRM1. In total, 193 participants (46.2%) experienced pain. Compared to pain-free PD patients, PD patients with pain had an earlier age of onset, longer disease duration, and higher depression and motor severity (P < 0.01). The frequencies of COMT rs4680 "A" allele were higher in PD patients with pain than those without pain (46.1% vs. 31.1%, P < 0.01). Pain severity was significantly associated with disease duration (P = 0.02), and COMT rs6267 T allele (P < 0.01). We stratified PD by status of depression and the association between COMT rs6267 "GT" genotype and pain severity remained significant (P < 0.01). Furthermore, pain severity was significantly higher in participants having COMT rs4680 "GG" and "GA" genpotypes than those having "AA" genotype (P = 0.04). We concluded that depression and COMT rs4680 "GG" and "GA" genotypes and COMT rs6267 "GT" genotype contribute to pain in PD patients.
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