ArticleScientific reports2017
Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 55 citations in OpenAlex.
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- Utility of Minimal Physiologically Based Pharmacokinetic Models for Assessing Fractional Distribution, Oral Absorption, and Series-Compartment Models of Hepatic Clearance.Drug metabolism and disposition: the biological fate of chemicals · 2023Article
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- Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species.CPT: pharmacometrics & systems pharmacology · 2023Article
- Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice.Frontiers in pharmacology · 2023Article
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- Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.Archives of toxicology · 2022Article
- Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.Archives of toxicology · 2022Article
- From Seeing to Simulating: A Survey of Imaging Techniques and Spatially-Resolved Data for Developing Multiscale Computational Models of Liver Regeneration.Frontiers in systems biology · 2022Article
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- Subcellular spatio-temporal intravital kinetics of aflatoxin BArchives of toxicology · 2021Article
- Cross-species analysis of hepatic cytochrome P450 and transport protein expression.Archives of toxicology · 2021Article
- A workflow to build PBTK models for novel species.Archives of toxicology · 2020Article
- Hepatotoxicity of pyrrolizidine alkaloids in rats in relation to human exposure.Archives of toxicology · 2020Article
- Kupffer cells in hepatotoxicity.EXCLI journal · 2020Article
- Do artificial sweeteners increase the risk of non-alcoholic fatty liver disease (NAFLD)?EXCLI journal · 2020Article
- Highlight report: New insights in liver physiology: Canalicular bile flux is diffusion dominated.EXCLI journal · 2020Article
- Influence of Liver Fibrosis on Lobular Zonation.Cells · 2019Article
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Authors and funding
11 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diseases and toxins may lead to death of active liver tissue, resulting in a loss of total clearance capacity at the whole-body level. However, it remains difficult to study, whether the loss of metabolizing tissue is sufficient to explain loss of metabolic capacity of the liver or whether the surviving tissue undergoes an adaptive response to compensate the loss. To understand the cellular impact of toxic liver damage in an in vivo situation, we here used physiologically-based pharmacokinetic modelling to investigate pharmacokinetics of a specifically designed drug cocktail at three different sampling sites of the body in healthy mice and mice treated with carbon tetrachloride (CCl
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