ArticleNature communications2017
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03685149 (Pilot Randomized Trial With Flecainide in ARVC Patients), which is not on this map. Cited by 138 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
11.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Randomized Trial With Flecainide in ARVC Patients
Who cites it
138 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Arrhythmogenic Right Ventricular Cardiomyopathy in Pediatric Patients: An Important but Underrecognized Clinical Entity.Frontiers in pediatrics · 2021Pooled it
- Single nucleus RNA sequencing identifies PLXNA4 upregulation in end-stage arrhythmogenic right ventricular cardiomyopathy.iScience · 2026Article
- PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism.Cardiovascular research · 2026Article
- Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases.Cellular & molecular immunology · 2026Article
- Arrhythmogenic right ventricular cardiomyopathy.European heart journal · 2026Review
- Decreasing Microtubule Detyrosination Improves Cardiac Mechanics and Sodium Channel Function in Arrhythmogenic Cardiomyopathy.Circulation. Arrhythmia and electrophysiology · 2026Article
- Epicardial Contributions to Fibro-Inflammatory Signaling in a Pkp2-Deficient Arrhythmogenic Cardiomyopathy Model.Circulation. Heart failure · 2026Article
- Epigenetic and chromatin remodeling mechanisms across cardiomyopathies: a comprehensive review.Epigenetics & chromatin · 2026Review
- Article
- Review
- Cardiomyocyte-Specific Plakophilin-2 Loss Is Sufficient to Induce Aging and Senescence of Nonmyocytes: Relevance to Arrhythmogenic Cardiomyopathy.Journal of the American Heart Association · 2026Article
- Disease models and AAV therapies ofMolecular therapy. Advances · 2026Review
- Gene Therapy for Heart Failure.Journal of cardiovascular translational research · 2026Review
- Body surface potential mapping of ventricular depolarization and repolarization in phospholamban and plakophilin-2 cardiomyopathy.Heart rhythm O2 · 2026Article
- Decreased RYR2 Cluster Size and Abnormal SR CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions.JACC. Basic to translational science · 2025Article
- Exercise-induced dysregulation of the adrenergic response in a mouse model of PKP2-arrhythmogenic cardiomyopathy.Heart rhythm · 2025Article
- Arrhythmogenic Cardiomyopathy: Towards Genotype Based Diagnoses and Management.Journal of cardiovascular electrophysiology · 2025Review
- Atrial cardiomyopathy resulting from loss of plakophilin-2 expression: Response to adrenergic stimulation and implications for the exercise response.The Journal of physiology · 2025Article
- Comprehensive analysis of desmosomal protein remodelling identifies desmocollin-2 as potential biomarker for arrhythmogenic cardiomyopathy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 6 institutions in 2 countries.
Marina CerroneLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Jerome MontnachLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Xianming LinLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Yan-Ting ZhaoCenter for Arrhythmia Research, Division of Cardiology, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Mingliang ZhangLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Esperanza Agullo-PascualLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Alejandra Leo-MaciasLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Francisco J AlvaradoDepartment of Molecular and Integrative Physiology, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0003-0552-9029
Igor DolgalevGenome Technology Center, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0003-4451-126X
Thomas V KarathanosInstitute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, 3400N Charles St., Baltimore, MD, 21218, USA.
Kabir MalkaniLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0001-9942-1494
Chantal J M Van OpbergenDepartment of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht, Yalelaan 50, 3584CM, Utrecht, The Netherlands.
Joanne J A van BavelDepartment of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht, Yalelaan 50, 3584CM, Utrecht, The Netherlands.
Hua-Qian YangDepartment of Pediatrics, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Carolina VasquezLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
David TesterDepartments of Cardiovascular Diseases/Division of Heart Rhythm Services, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Steven FowlerLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Fengxia LiangDepartment of Cell Biology and Microscopy Core, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Eli RothenbergDepartment of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Adriana HeguyGenome Technology Center, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Gregory E MorleyLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
William A CoetzeeDepartments of Pediatrics, Physiology & Neuroscience and Biochemistry and Molecular Pharmacology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA.
Natalia A TrayanovaInstitute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, 3400N Charles St., Baltimore, MD, 21218, USA.
Michael J AckermanDepartments of Cardiovascular Diseases/Division of Heart Rhythm Services, Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Toon A B van VeenDepartment of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht, Yalelaan 50, 3584CM, Utrecht, The Netherlands.
Hector H ValdiviaCenter for Arrhythmia Research, Division of Cardiology, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.
Mario DelmarLeon H Charney Division of Cardiology, NYU School of Medicine, 520 First Avenue, New York, NY, 10016, USA. Mario.delmar@nyumc.org.
New York University · USUniversity Medical Center Utrecht · NLUniversity of Michigan · USJohns Hopkins University · USMayo Clinic · USNew York Genome Center · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MRyanodine Receptors, Calcium-dependent Arrhythmias & HCMR01HL055438 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 1996 to 2023
$8.0MPH REGULATION OF CONNEXIN43--INTERMEDIARY STEPSR01GM057691 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI DELMAR, MARIO · 1999 to 2016
$5.6MIntercellular Communication and Cardiac ArrhythmiasR01HL076751 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MORLEY, GREGORY E · 2005 to 2017
$5.6MVirtual Electrophysiology LaboratoryDP1HL123271 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2013 to 2017
$4.0MRole of PKP2 in epicardial structure and functionR01HL136179 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DELMAR, MARIO, MORLEY, GREGORY E · 2017 to 2020
$3.1MExploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8MKATP Channel Trafficking and CardioprotectionR01HL126905 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COETZEE, WILLIAM A · 2015 to 2018
$2.7MRole of desmosomes in cardiac electrical functionR01HL134328 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DELMAR, MARIO, MORLEY, GREGORY E · 2016 to 2019
$2.6MSingle-Molecule Studies of Non-Homologous DNA End JoiningR01GM108119 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ROTHENBERG, ELI · 2015 to 2019
$1.7MCytosolic Calcium Sweeper in Cardiac MyocytesR01HL120108 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VALDIVIA, HECTOR H · 2014 to 2017
$1.5MSingle-molecule studies of BRCA1-BACH1 mechanism in genomic integrityR21CA187612 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ROTHENBERG, ELI · 2015 to 2016
$451kNCI NIH HHS P30 CA016087NCI NIH HHS R21 CA187612NHLBI NIH HHS DP1 HL123271NHLBI NIH HHS R01 HL055438NHLBI NIH HHS R01 HL076751NHLBI NIH HHS R01 HL120108NHLBI NIH HHS R01 HL126802NHLBI NIH HHS R01 HL126905NHLBI NIH HHS R01 HL134328NHLBI NIH HHS R01 HL136179NIGMS NIH HHS R01 GM057691NIGMS NIH HHS R01 GM108119
Abstract
Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell-cell adhesion. Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of right ventricular predominance. Here, we use a range of state-of-the-art methods and a cardiomyocyte-specific, tamoxifen-activated, PKP2 knockout mouse to demonstrate that in addition to its role in cell adhesion, PKP2 is necessary to maintain transcription of genes that control intracellular calcium cycling. Lack of PKP2 reduces expression of Ryr2 (coding for Ryanodine Receptor 2), Ank2 (coding for Ankyrin-B), Cacna1c (coding for Ca
Indexed as
Transcription, GeneticAnimalsArrhythmias, CardiacBlotting, WesternCalciumGene ExpressionHeartHumansMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalMyocardiumMyocytes, CardiacPlakophilinsReverse Transcriptase Polymerase Chain ReactionCalciumPlakophilins
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
NCT03685149ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.