ArticleScientific reports2017
Obesity, adipokines, and C-peptide are associated with distinct plasma phospholipid profiles in adult males, an untargeted lipidomic approach.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Untargeted metabolomics unveils metabolic biomarkers in HFpEF.Frontiers in molecular biosciences · 2025Article
- Risk Factors for Early Post-transplant Weight Changes Among Simultaneous Pancreas-kidney Recipients and Impact on Outcomes.Transplantation direct · 2024Article
- Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood.Metabolites · 2023Article
- Global and Partial Effect Assessment in Metabolic Syndrome Explored by Metabolomics.Metabolites · 2023Article
- Associations of Early Pregnancy Metabolite Profiles with Gestational Blood Pressure Development.Metabolites · 2022Article
- Fetal Exposure to Maternal Smoking and Neonatal Metabolite Profiles.Metabolites · 2022Article
- Pre-Operative Assessment of Micronutrients, Amino Acids, Phospholipids and Oxidative Stress in Bariatric Surgery Candidates.Antioxidants (Basel, Switzerland) · 2022Article
- Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice.Biomedicines · 2022Article
- Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease.Nature medicine · 2022Article
- Untargeted Metabolomics Analysis of the Serum Metabolic Signature of Childhood Obesity.Nutrients · 2022Article
- Maternal Body Mass Index, Early-Pregnancy Metabolite Profile, and Birthweight.The Journal of clinical endocrinology and metabolism · 2022Observational
- Homocysteine level, body mass index and clinical correlates in Chinese Han patients with schizophrenia.Scientific reports · 2020Article
- Visceral fat-related systemic inflammation and the adolescent brain: a mediating role of circulating glycerophosphocholines.International journal of obesity (2005) · 2019Article
- Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients.Translational psychiatry · 2018Article
- Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment.British journal of cancer · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Obesity is associated with dysregulated lipid metabolism and adipokine secretion. Our group has previously reported obesity and adipokines are associated with % total fatty acid (FA) differences in plasma phospholipids. The objective of our current study was to identify in which complex lipid species (i.e., phosphatidylcholine, sphingolipids, etc) these FA differences occur. Plasma lipidomic profiling (n = 126, >95% Caucasian, 48-65 years) was performed using chromatographic separation and high resolution tandem mass spectrometry. The responses used in the statistical analyses were body mass index (BMI), waist circumference (WC), serum adipokines, cytokines, and a glycemic marker. High-dimensional statistical analyses were performed, all models were adjusted for age and smoking, and p-values were adjusted for false discovery. In Bayesian models, the lipidomic profiles (over 1,700 lipids) accounted for >60% of the inter-individual variation of BMI, WC, and leptin in our population. Across statistical analyses, we report 51 individual plasma lipids were significantly associated with obesity. Obesity was inversely associated lysophospholipids and ether linked phosphatidylcholines. In addition, we identify several unreported lipids associated with obesity that are not present in lipid databases. Taken together, these results provide new insights into the underlying biology associated with obesity and reveal new potential pathways for therapeutic targeting.
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