Evidence map›Paper›PMID 28740106›Full record

ArticleScientific reports2017

Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.

Yong Song, Michelle J Schwager, Vibeke Backer, Jing Guo, Celeste Porsbjerg, Siew-Kim Khoo, Ingrid A Laing, Eric K Moses, Peter LeSouëf, Guicheng Brad Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Yong SongSchool of Public Health, Curtin University, Kent St, Bentley, 6102, Western Australia, Australia.
Michelle J SchwagerSchool of Paediatrics and Child Health, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia.
Vibeke BackerDepartment of Respiratory medicine, Bispebjerg University hospital, Copenhagen University, Copenhagen, Denmark.
Jing GuoSchool of Public Health, Curtin University, Kent St, Bentley, 6102, Western Australia, Australia.
Celeste PorsbjergDepartment of Respiratory medicine, Bispebjerg University hospital, Copenhagen University, Copenhagen, Denmark.
Siew-Kim KhooSchool of Paediatrics and Child Health, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia.
Ingrid A LaingSchool of Paediatrics and Child Health, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia.
Eric K MosesCentre for Genetic Origins of Health and Disease, The University of Western Australia and Curtin University, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia.
Peter LeSouëfSchool of Paediatrics and Child Health, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, Western Australia, Australia.
Guicheng Brad ZhangSchool of Public Health, Curtin University, Kent St, Bentley, 6102, Western Australia, Australia. brad.zhang@curtin.edu.au.
University of Western Australia · AUCurtin University · AUBispebjerg Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of asthma and allergic diseases is disproportionately distributed among different populations, with an increasing trend observed in Western countries. Here we investigated how the environment affected genotype-phenotype association in a genetically homogeneous, but geographically separated population. We evaluated 18 single nucleotide polymorphisms (SNPs) corresponding to 8 genes (ADAM33, ALOX5, LT-α, LTC4S, NOS1, ORMDL3, TBXA2R and TNF-α), the lung function and five respiratory/allergic conditions (ever asthma, bronchitis, rhinitis, dermatitis and atopy) in two populations of Inuit residing either in the westernized environment of Denmark or in the rural area of Greenland. Our results showed that lung function was associated with genetic variants in ORMDL3, with polymorphisms having a significant interaction with place of residence. LT-α SNP rs909253 and rs1041981 were significantly associated with bronchitis risk. LT-α SNP rs2844484 was related to dermatitis susceptibility and was significantly influenced by the place of residence. The observed gene-phenotype relationships were exclusively present in one population and absent in the other population. We conclude that the genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment and that environmental factors/lifestyles modify genetic predisposition and change the genetic effects on diseases.

Indexed as

Polymorphism, Single NucleotideAdultAsthmaBronchitisCase-Control StudiesDenmarkDermatitis, AtopicFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseGreenlandHumansInuitLymphotoxin-alphaMaleLTA protein, humanLymphotoxin-alphaMembrane ProteinsORMDL3 protein, human

Identifiers

PMID28740106
PMCPMC5524954
OpenAlexW2736878676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.