ArticleScientific reports2017
Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 94 citations in OpenAlex.
- Bioactive Molecules Niosomes Containing a Span 80 and Tween 20 Surfactant Mixture: Obtaining, Physico-Chemical Characterisation and Stability.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Clinical pharmacist-led prevention of intravenous drug incompatibilities in an adult ICU: a prospective observational study.BMC pharmacology & toxicology · 2026Observational
- Chitosan-coated silver nanoparticles amplify glycopeptide efficacy againstFrontiers in microbiology · 2026Article
- Preparation and characterization of niosomes containing silver nanoparticles as a radiosensitizer for enhancing radiotherapy of the lung cancer.Scientific reports · 2025Article
- Balanced enhancement of antibacterial activity and biocompatibility in chitosan-vancomycin 3D-printed scaffolds through mesoporous bioactive glass addition.Journal of drug delivery science and technology · 2025Article
- Soluplus-Stabilized Nimodipine-Entrapped Spanlastic Formulations Prepared with Edge Activator (Tween20): Comparative Physicochemical Evaluation.Pharmaceutical nanotechnology · 2025Article
- Mesoporous FeRSC advances · 2024Article
- Development of brimonidine niosomes laden contact lenses for extended release and promising delivery system in glaucoma treatment.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Engineering 5-flourouracil and leucovorin-loaded vesicular systems for possible colon specific delivery:Heliyon · 2024Article
- Niosomes loaded with gold nanoparticles for enhanced radiation therapy in lung cancer.Nanomedicine (London, England) · 2024Article
- Advanced Drug Delivery Technologies for Enhancing Bioavailability and Efficacy of Risperidone.International journal of nanomedicine · 2024Review
- Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study.International journal of pharmaceutics: X · 2023Article
- Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats.Drug delivery · 2023Article
- Electrospun PCL Wires Loaded with Vancomycin on Zirconium Substrate.Materials (Basel, Switzerland) · 2023Article
- Article
- Efficient targeting of HIF-1α mediated by YC-1 and PX-12 encapsulated niosomes: potential application in colon cancer therapy.Journal of biological engineering · 2023Article
- Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities.Scientific reports · 2022Article
- Article
- Development and In Vitro and In Vivo Evaluation of an Antineoplastic Copper(II) Compound (Casiopeina III-ia) Loaded in Nonionic Vesicles Using Quality by Design.International journal of molecular sciences · 2022Article
- UMAOH Calcium Phosphate Coatings Designed for Drug Delivery: Vancomycin, 5-Fluorouracil, Interferon α-2b Case.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug incompatibilities are considered as one of the most critical problems in intensive care units. In the current study, the ability of nanomaterials to prevent drug incompatibilities in clinical settings has been investigated. As a proof-of-concept, the ability of niosomes to prevent physical and chemical incompatibilities that occur upon mixing acyclovir and vancomycin during management of acute meningitis has been explored. Nanosized spherical particles loaded separately with either vancomycin or acyclovir, with high entrapment efficiency (ca. 46-56%), could be prepared, and sustained release of their entrapped cargoes have been demonstrated over time. We have shown that precipitation, degradation and loss of biological activity of drugs occurred upon mixing solutions of the free drugs. On the contrary, drugs loaded separately inside niosomal structures exhibited high stability, exceptional physical and chemical compatibilities for up to 48 h with complete preservation of the antimicrobial activity of vancomycin. This study opens a venue for a new spectrum of applications of nanomaterials in preventing clinically significant drug incompatibilities, aiming at the reduction of adverse reactions, cost and hospitalization period, and improvement of patient compliance and therapeutic outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.