Evidence map›Paper›PMID 28740086›Full record

ArticleScientific reports2017

Novel Molecule Exhibiting Selective Affinity for GABA

Cecilia M Borghese, Melissa Herman, Lawrence D Snell, Keri J Lawrence, Hyun-Young Lee, Donald S Backos, Lauren A Vanderlinden, R Adron Harris, Marisa Roberto, Paula L Hoffman and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Allosteric Modulation of GABAACS pharmacology & translational science · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Cecilia M BorgheseThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX, 78712, USA.ORCID 0000-0002-1028-8277
Melissa HermanDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Lawrence D SnellLohocla Research Corporation, Aurora, CO, 80045, USA.
Keri J LawrenceThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX, 78712, USA.
Hyun-Young LeeThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX, 78712, USA.
Donald S BackosDepartment of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CO, 80045, USA.ORCID 0000-0001-6735-6210
Lauren A VanderlindenDepartment of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences, Aurora, CO, 80045, USA.
R Adron HarrisThe University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX, 78712, USA.
Marisa RobertoDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Paula L HoffmanLohocla Research Corporation, Aurora, CO, 80045, USA.
Boris TabakoffLohocla Research Corporation, Aurora, CO, 80045, USA. boris.tabakoff@ucdenver.edu.
The University of Texas at Austin · USLohocla Research Corporation (United States) · USScripps Research Institute · USUniversity of Montana · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Integrative Neuroscience Initiative on Alcoholism - West - SupplementU01AA013517 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2001 to 2014
$12.7M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
BRAIN MEMBRANES IN ALCOHOL AND BENZODIAZEPINE DEPENDENCER01AA006399 · NIAAA · UNIVERSITY OF TEXAS AUSTIN · PI HARRIS, ROBERT A · 1985 to 2018
$8.8M
Nezavist a Novel Molecule for Treatment of Alcohol Use DisorderU44AA024905 · NIAAA · LOHOCLA RESEARCH CORPORATION · PI TABAKOFF, BORIS · 2015 to 2021
$7.7M
Integrative Neuroscience Initiative on AlcoholismU24AA025479 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI ROBERT O. MESSING · 2017 to 2026
$5.0M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Integrative Neuroscience Initiative on AlcoholismU24AA013517 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2015 to 2016
$1.5M
Medications for the Treatment of Alcohol Abuse and Dependence and RelapseR44AA009930 · NIAAA · LOHOCLA RESEARCH CORPORATION · PI SNELL, LAWRENCE DOUGLAS · 1997 to 2009
$1.1M
Alcohol-induced plasticity within CRF2 microcircuits in distinct amygdala nucleiR00AA023002 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HERMAN, MELISSA A · 2017 to 2019
$732k
NCATS NIH HHS UL1 TR001082NIAAA NIH HHS R00 AA023002NIAAA NIH HHS R01 AA006399NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R44 AA009930NIAAA NIH HHS U01 AA013498NIAAA NIH HHS U01 AA013517NIAAA NIH HHS U24 AA013517NIAAA NIH HHS U24 AA025479NIAAA NIH HHS U44 AA024905
6 · The paper itself

Abstract

Aminoquinoline derivatives were evaluated against a panel of receptors/channels/transporters in radioligand binding experiments. One of these derivatives (DCUK-OEt) displayed micromolar affinity for brain γ-aminobutyric acid type A (GABA

Indexed as

AnimalsBinding SitesBrainCentral Amygdaloid NucleusGABA Modulatorsgamma-Aminobutyric AcidMaleModels, MolecularNeuronsProtein ConformationProtein SubunitsRadioligand AssayRatsRats, Sprague-DawleyReceptors, GABA-AXenopus laevisGABA Modulatorsgamma-Aminobutyric AcidProtein SubunitsReceptors, GABA-A

Identifiers

PMID28740086
PMCPMC5524711
OpenAlexW2737658934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.