Evidence map›Paper›PMID 28739977›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

MicroRNA-210 Targets Ten-Eleven Translocation Methylcytosine Dioxygenase 1 and Suppresses Pregnancy-Mediated Adaptation of Large Conductance Ca

Xiang-Qun Hu, Chiranjib Dasgupta, Daliao Xiao, Xiaohui Huang, Shumei Yang, Lubo Zhang

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024
    Guideline
  2. Review
  3. Review
  4. The uteroplacental circulation at high altitude: adaptation and maladaptation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  5. Fetal growth and congenital heart disease at high altitude.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  6. Article
  7. Rad-mediated inhibition of CaThe Journal of physiology · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. CaInternational journal of molecular sciences · 2023
    Review
  13. Oxidative Regulation of Vascular CaAntioxidants (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiang-Qun HuFrom the Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, CA (X.-Q.H., C.D., D.X., X.H., L.Z.); and Department of Chemistry and Biochemistry, California State University, San Bernardino (S.Y.).
Chiranjib DasguptaFrom the Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, CA (X.-Q.H., C.D., D.X., X.H., L.Z.); and Department of Chemistry and Biochemistry, California State University, San Bernardino (S.Y.).
Daliao XiaoFrom the Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, CA (X.-Q.H., C.D., D.X., X.H., L.Z.); and Department of Chemistry and Biochemistry, California State University, San Bernardino (S.Y.).
Xiaohui HuangFrom the Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, CA (X.-Q.H., C.D., D.X., X.H., L.Z.); and Department of Chemistry and Biochemistry, California State University, San Bernardino (S.Y.).
Shumei YangFrom the Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, CA (X.-Q.H., C.D., D.X., X.H., L.Z.); and Department of Chemistry and Biochemistry, California State University, San Bernardino (S.Y.).
Lubo ZhangFrom the Lawrence D. Longo, MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, CA (X.-Q.H., C.D., D.X., X.H., L.Z.); and Department of Chemistry and Biochemistry, California State University, San Bernardino (S.Y.). lzhang@llu.edu.
Loma Linda University · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
Epigenetic mechanisms of uterine vascular adaptation to pregnancy and hypoxiaR01HL128209 · NHLBI · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2015 to 2018
$1.6M
Uterine Arterial Spontaneous Transient Outward Currents in PregnancyR01HL137649 · NHLBI · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2017 to 2020
$1.6M
DNA Demethylation and BKca Channel Expression and Function in Uterine ArteriesR21HD083232 · NICHD · LOMA LINDA UNIVERSITY · PI ZHANG, LUBO · 2015 to 2016
$433k
NHLBI NIH HHS R01 HL128209NHLBI NIH HHS R01 HL137649NICHD NIH HHS P01 HD083132NICHD NIH HHS R21 HD083232
6 · The paper itself

Abstract

Gestational hypoxia inhibits large conductance Ca

Indexed as

blood pressureDNA methylationhypoxiapre-eclampsiavascular resistance

Identifiers

PMID28739977
PMCPMC5783798
OpenAlexW2737722865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.