ArticleProceedings of the National Academy of Sciences of the United States of America2017
Neural basis for hand muscle synergies in the primate spinal cord.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04154514 (A Wearable for Post-stroke Rehabilitative Multi-muscle Stimulation Inspired by the Natural Organization of Neuromuscular Control), which is not on this map. Cited by 82 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Wearable for Post-stroke Rehabilitative Multi-muscle Stimulation Inspired by the Natural Organization of Neuromuscular Control
Who cites it
82 citing papers in PubMed, 172 citations in OpenAlex.
- A randomized controlled trial on the effects induced by robot-assisted and usual-care rehabilitation on upper limb muscle synergies in post-stroke subjects.Scientific reports · 2021Trial
- Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An explicit strategy facilitates adaptation to virtual surgeries by biasing the recruitment of existing synergies.iScience · 2026Article
- Article
- Adaptation-dependent modulation of coordinated muscle activities in human gait adaptation as revealed by tensor decomposition.iScience · 2026Article
- Overlap in neural representations of coordinated wrist and finger movements in human motor cortex.bioRxiv : the preprint server for biology · 2026Article
- Autogenic spinal excitatory circuit ensures skilled hand movements in primates.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A modular architecture for trial-by-trial learning of redundant muscle activity patterns in novel sensorimotor tasks.PLoS computational biology · 2026Article
- Primate dexterous hand movements are controlled by functionally distinct premotoneuronal systems.Science advances · 2026Article
- Functional symmetrization of neuromotor modules during locomotor development in human infants.Communications biology · 2025Article
- EMG-guided human-machine interaction training develops new intermuscular coordination patterns in stroke: a pilot study.Journal of neuroengineering and rehabilitation · 2025Article
- Decoding multi-joint hand movements from brain signals by learning a synergy-based neural manifold.Patterns (New York, N.Y.) · 2025Article
- Developmental changes in upper limb muscle synergies during throwing: A comparison between preschoolers and schoolers.iScience · 2025Article
- State-dependent neural representations of muscle synergies in the spinal cord revealed by optogenetic stimulation.The Journal of physiology · 2025Article
- Can EMG-Derived Upper Limb Muscle Synergies Serve as Markers for Post-Stroke Motor Assessment and Prediction of Rehabilitation Outcome?Sensors (Basel, Switzerland) · 2025Article
- Frequency-specific intermuscular coherence of synergistic muscles during an isometric force generation task.Frontiers in neural circuits · 2025Article
- Muscle synergy in several locomotor modes in chimpanzees and Japanese macaques, and its implications for the evolutionary origin of bipedalism through shared muscle synergies.Scientific reports · 2024Article
- Article
- Muscle synergies in upper limb stroke rehabilitation: a scoping review.European journal of physical and rehabilitation medicine · 2024Article
- The Volitional Control of Individual Motor Units Is Constrained within Low-Dimensional Neural Manifolds by Common Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Grasping is a highly complex movement that requires the coordination of multiple hand joints and muscles. Muscle synergies have been proposed to be the functional building blocks that coordinate such complex motor behaviors, but little is known about how they are implemented in the central nervous system. Here we demonstrate that premotor interneurons (PreM-INs) in the primate cervical spinal cord underlie the spatiotemporal patterns of hand muscle synergies during a voluntary grasping task. Using spike-triggered averaging of hand muscle activity, we found that the muscle fields of PreM-INs were not uniformly distributed across hand muscles but rather distributed as clusters corresponding to muscle synergies. Moreover, although individual PreM-INs have divergent activation patterns, the population activity of PreM-INs reflects the temporal activation of muscle synergies. These findings demonstrate that spinal PreM-INs underlie the muscle coordination required for voluntary hand movements in primates. Given the evolution of neural control of primate hand functions, we suggest that spinal premotor circuits provide the fundamental coordination of multiple joints and muscles upon which more fractionated control is achieved by superimposed, phylogenetically newer, pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.