ArticleProceedings of the National Academy of Sciences of the United States of America2017
Synthetic quorum sensing in model microcapsule colonies.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Autoinducer 2 as a universal language in microbial consortia: decoding molecular mechanisms, ecological impacts, and application.Gut microbes · 2026Review
- Chemical signaling in reaction networks generates corresponding mechanical impulses.PNAS nexus · 2025Article
- Interlinking spatial dimensions and kinetic processes in dissipative materials to create synthetic systems with lifelike functionality.Nature nanotechnology · 2024Review
- Quantifying the optimal strategy of population control of quorum sensing network in Escherichia coli.NPJ systems biology and applications · 2021Article
- Reaction-diffusion hydrogels from urease enzyme particles for patterned coatings.Communications chemistry · 2021Article
- Bottom-Up Construction of Complex Biomolecular Systems With Cell-Free Synthetic Biology.Frontiers in bioengineering and biotechnology · 2020Review
- Modelling Bacteria-Inspired Dynamics with Networks of Interacting Chemicals.Life (Basel, Switzerland) · 2019Article
- Functional Dynamics Inside Nano- or Microscale Bio-Hybrid Systems.Frontiers in chemistry · 2018Review
- Switches induced by quorum sensing in a model of enzyme-loaded microparticles.Journal of the Royal Society, Interface · 2017Article
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Authors and funding
2 authors.
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Abstract
Biological quorum sensing refers to the ability of cells to gauge their population density and collectively initiate a new behavior once a critical density is reached. Designing synthetic materials systems that exhibit quorum sensing-like behavior could enable the fabrication of devices with both self-recognition and self-regulating functionality. Herein, we develop models for a colony of synthetic microcapsules that communicate by producing and releasing signaling molecules. Production of the chemicals is regulated by a biomimetic negative feedback loop, the "repressilator" network. Through theory and simulation, we show that the chemical behavior of such capsules is sensitive to both the density and number of capsules in the colony. For example, decreasing the spacing between a fixed number of capsules can trigger a transition in chemical activity from the steady, repressed state to large-amplitude oscillations in chemical production. Alternatively, for a fixed density, an increase in the number of capsules in the colony can also promote a transition into the oscillatory state. This configuration-dependent behavior of the capsule colony exemplifies quorum-sensing behavior. Using our theoretical model, we predict the transitions from the steady state to oscillatory behavior as a function of the colony size and capsule density.
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