Evidence map›Paper›PMID 28739894›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance.

Radoslaw Pluta, D Roeland Boer, Fabián Lorenzo-Díaz, Silvia Russi, Hansel Gómez, Cris Fernández-López, Rosa Pérez-Luque, Modesto Orozco, Manuel Espinosa, Miquel Coll

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Microorganisms · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Regulation of Gram-Positive Conjugation.Frontiers in microbiology · 2019
    Review
  17. Article
  18. Article
  19. TheFrontiers in microbiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Radoslaw PlutaInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.ORCID 0000-0002-1676-860X
D Roeland BoerInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Fabián Lorenzo-DíazBiological Research Center, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Silvia RussiInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Hansel GómezInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Cris Fernández-LópezBiological Research Center, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Rosa Pérez-LuqueInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Modesto OrozcoInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.
Manuel EspinosaBiological Research Center, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
Miquel CollInstitute for Research in Biomedicine, Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; miquel.coll@irbbarcelona.org.
Consejo Superior de Investigaciones Científicas · ESInstitute for Research in Biomedicine · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Relaxases are metal-dependent nucleases that break and join DNA for the initiation and completion of conjugative bacterial gene transfer. Conjugation is the main process through which antibiotic resistance spreads among bacteria, with multidrug-resistant staphylococci and streptococci infections posing major threats to human health. The MOB

Indexed as

DNA Breaks, Single-StrandedModels, MolecularBacterial ProteinsDNA, BacterialEndodeoxyribonucleasesHistidinePlasmidsStaphylococcus aureusBacterial ProteinsDNA, BacterialEndodeoxyribonucleasesHistidineMobM protein, bacteriaantibiotic resistancehistidine relaxasehorizontal gene transferStaphylococcus aureusX-ray structure

Identifiers

PMID28739894
PMCPMC5559014
OpenAlexW2739935986

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.