ArticleThe Journal of biological chemistry2017
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
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Who cites it
53 citing papers in PubMed, 72 citations in OpenAlex.
- LGR5: from stem cell marker to therapeutic target.Trends in cancer · 2026Review
- Sphingosine-1-Phosphate Receptor 3 Confers Tumor Metastasis in Lung Cancer Resistant to Third-Generation EGFR Inhibitor.MedComm · 2026Article
- LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance.Cancer metastasis reviews · 2025Review
- Association between colorectal cancer stem cells' expression of LGR5 and the location of colorectal cancer.Gastroenterology and hepatology from bed to bench · 2025Article
- Menin in Cancer.Genes · 2024Review
- Novel immunotherapeutics against LGR5 to target multiple cancer types.EMBO molecular medicine · 2024Article
- Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma.Pharmaceutics · 2024Article
- The Roles of RAC1 and RAC1B in Colorectal Cancer and Their Potential Contribution to Cetuximab Resistance.Cancers · 2024Review
- Leucine-rich repeat-containing G protein-coupled receptor 5 expression in lymph node metastases of colorectal cancer: Clinicopathological insights and prognostic implications.Pathology international · 2024Article
- Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging.Cell cycle (Georgetown, Tex.) · 2024Article
- The association and clinicopathological significance of Integrin alphavbeta6 and Rac1 expression in gastric carcinoma.Frontiers in oncology · 2024Article
- Advanced Progression for the Heterogeneity and Homeostasis of Intestinal Stem Cells.Stem cell reviews and reports · 2023Review
- LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands.Scientific reports · 2023Article
- G protein-coupled receptor-targeting antibody-drug conjugates: Current status and future directions.Cancer letters · 2023Review
- The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling.The Journal of cell biology · 2023Review
- Loss of LGR5 through Therapy-induced Downregulation or Gene Ablation Is Associated with Resistance and Enhanced MET-STAT3 Signaling in Colorectal Cancer Cells.Molecular cancer therapeutics · 2023Article
- Menin represses the proliferation of gastric cancer cells by interacting with IQGAP1.Biomedical reports · 2023Article
- Review
- Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift.Life science alliance · 2022Article
- LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Kendra S CarmonFrom the Brown Foundation Institute of Molecular Medicine and Texas Therapeutics Institute, University of Texas Health Science Center, Houston, Texas 77030.
Xing GongFrom the Brown Foundation Institute of Molecular Medicine and Texas Therapeutics Institute, University of Texas Health Science Center, Houston, Texas 77030.
Jing YiFrom the Brown Foundation Institute of Molecular Medicine and Texas Therapeutics Institute, University of Texas Health Science Center, Houston, Texas 77030.
Ling WuFrom the Brown Foundation Institute of Molecular Medicine and Texas Therapeutics Institute, University of Texas Health Science Center, Houston, Texas 77030.
Anthony ThomasFrom the Brown Foundation Institute of Molecular Medicine and Texas Therapeutics Institute, University of Texas Health Science Center, Houston, Texas 77030.
Catherine M MooreSchool of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Ireland, United Kingdom.
Ikuo MasuhoDepartment of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, and.
David J TimsonSchool of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Ireland, United Kingdom.
Kirill A MartemyanovDepartment of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458, and.
Qingyun J LiuFrom the Brown Foundation Institute of Molecular Medicine and Texas Therapeutics Institute, University of Texas Health Science Center, Houston, Texas 77030, Qingyun.liu@uth.tmc.edu.ORCID 0000-0001-7683-5088
Brown Foundation · USQueen's University Belfast · GBScripps Research Institute · USThe University of Texas MD Anderson Cancer Center · US
Funding
Orphan Receptors in Regulation of Neuronal G Protein SignalingR01MH105482 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov · 2015 to 2026
$6.1MFunction and mechanism of LGR4 and LGR5 in Modulation of Wnt SignalingR01GM102485 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, QINGYUN · 2012 to 2020
$2.1MMolecular Basis of RGS Protein Function in the StriatumK02DA026405 · NIDA · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A. · 2009 to 2019
$1.2MBiotechnology and Biological Sciences Research Council BB/D000394/1NIDA NIH HHS K02 DA026405NIGMS NIH HHS R01 GM102485NIMH NIH HHS R01 MH105482
Abstract
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a
Indexed as
Cell AdhesionAnimalsCells, CulturedCHO CellsColonic NeoplasmsCricetulusHEK293 CellsHumansrac1 GTP-Binding Proteinras GTPase-Activating ProteinsReceptors, G-Protein-CoupledStem CellsIQ motif containing GTPase activating protein 1LGR5 protein, humanrac1 GTP-Binding ProteinRAC1 protein, humanras GTPase-Activating ProteinsReceptors, G-Protein-Coupled7-helix receptoradhesioncancer stem cellsG protein-coupled receptor (GPCR)intestine
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.