Evidence map›Paper›PMID 28739790›Full record

ArticleAntimicrobial agents and chemotherapy2017

A Cationic Polymer That Shows High Antifungal Activity against Diverse Human Pathogens.

Leslie A Rank, Naomi M Walsh, Runhui Liu, Fang Yun Lim, Jin Woo Bok, Mingwei Huang, Nancy P Keller, Samuel H Gellman, Christina M Hull

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Beyond nylon 6: polyamidesChemical Society reviews · 2022
    Review
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Leslie A RankDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Naomi M WalshDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Runhui LiuDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Fang Yun LimDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jin Woo BokDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mingwei HuangDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA npkeller@wisc.edu gellman@chem.wisc.edu cmhull@wisc.edu.
Samuel H GellmanDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA npkeller@wisc.edu gellman@chem.wisc.edu cmhull@wisc.edu.
Christina M HullDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA npkeller@wisc.edu gellman@chem.wisc.edu cmhull@wisc.edu.
University of Wisconsin–Madison · US

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
Mechanisms of an Aspergillus fumigatus virulence mutantR01AI065728 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2006 to 2017
$3.6M
Skin Diseases Research Center at the University of WisconsinP30AR066524 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI WOOD, GARY S · 2014 to 2018
$2.6M
Design and Analysis of Random Copolymers with Antimicrobial ActivityR01GM093265 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WEISSHAAR, JAMES C. · 2011 to 2018
$2.1M
Pathogenesis of Cryptococcus SporesR01AI089370 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 2010 to 2014
$1.7M
NIAID NIH HHS R01 AI065728NIAID NIH HHS R01 AI089370NIAMS NIH HHS P30 AR066524NIGMS NIH HHS R01 GM093265NIGMS NIH HHS T32 GM007215
6 · The paper itself

Abstract

Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic agents available to treat fungi are limited, and there is a critical need for new agents to combat these deadly infections. Antifungal compound development has been hindered by the challenge of creating agents that are highly active against fungal pathogens but not toxic to the host. Host defense peptides (HDPs) are produced by eukaryotes as a component of the innate immune response to pathogens and have served as inspiration for the development of many new antibacterial compounds. HDP mimics, however, have largely failed to exhibit potent and selective antifungal activity. Here, we present an HDP-like nylon-3 copolymer that is effective against diverse fungi while displaying only mild to moderate toxicity toward mammalian cells. This polymer is active on its own and in synergy with existing antifungal drugs against multiple species of

Indexed as

Amphotericin BAntifungal AgentsAntimicrobial Cationic PeptidesArabidopsisCandidaCryptococcusDrug Resistance, FungalDrug SynergismFluconazoleHumansImmunity, InnateMicrobial Sensitivity TestsNylonsPlant RootsPolymersAmphotericin BAntifungal AgentsAntimicrobial Cationic PeptidesFluconazoleNylonsPolymersantifungal agentsantimicrobial peptidesbroad spectrumdrug synergyfungal pathogenesisnylon-3 polymers

Identifiers

PMID28739790
PMCPMC5610528
OpenAlexW2736727523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.