Evidence map›Paper›PMID 28739787›Full record

ArticleAntimicrobial agents and chemotherapy2017

Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.

Kirk Nelson, Peera Hemarajata, Dongxu Sun, Debora Rubio-Aparicio, Ruslan Tsivkovski, Shangxin Yang, Robert Sebra, Andrew Kasarskis, Hoan Nguyen, Blake M Hanson and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Tandem amplification of theMicrobiology spectrum · 2026
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  5. Antimicrobial agents and chemotherapy · 2026
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  8. JAC-antimicrobial resistance · 2025
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  10. Multidrug-resistant hypervirulentFuture microbiology · 2025
    Review
  11. Article
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  13. Article
  14. Review
  15. Article
  16. Article
  17. Transferable AmpCs inAntimicrobial agents and chemotherapy · 2024
    Article
  18. Review
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Kirk NelsonThe Medicines Company, San Diego, California, USA.
Peera HemarajataPathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-6182-9136
Dongxu SunThe Medicines Company, San Diego, California, USA.
Debora Rubio-AparicioThe Medicines Company, San Diego, California, USA.
Ruslan TsivkovskiThe Medicines Company, San Diego, California, USA.
Shangxin YangDepartment of Pathology, University of New Mexico, Albuquerque, New Mexico, USA.
Robert SebraIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Andrew KasarskisIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Hoan NguyenJAX Genomic Medicine, Farmington, Connecticut, USA.
Blake M HansonJAX Genomic Medicine, Farmington, Connecticut, USA.
Shana LeopoldJAX Genomic Medicine, Farmington, Connecticut, USA.
George WeinstockJAX Genomic Medicine, Farmington, Connecticut, USA.
Olga LomovskayaThe Medicines Company, San Diego, California, USA.
Romney M HumphriesPathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA rhumphries@mednet.ucla.edu.
Doctors Company (United States) · USIcahn School of Medicine at Mount Sinai · USUniversity of California, Los Angeles · USUniversity of New Mexico · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceftazidime-avibactam is an antibiotic with activity against serine beta-lactamases, including

Indexed as

Azabicyclo CompoundsBacterial Proteinsbeta-LactamasesCarrier ProteinsCeftazidimeDNA Transposable ElementsDrug CombinationsDrug Resistance, Multiple, BacterialHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsPlasmidsPorinsTrans-Activatorsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-lactamase KPC-3, Klebsiella pneumoniaebeta-Lactamasesbeta-lactamase SHV-12carbapenemaseCarrier ProteinsCeftazidimeDNA Transposable ElementsDrug CombinationsOmpK35 porin, Klebsiella pneumoniaeOmpK36 protein, Klebsiella pneumoniaePorinsTrans-Activatorsceftazidime-avibactamKlebsiella pneumoniaeKPCporin mutationresistance

Identifiers

PMID28739787
PMCPMC5610495
OpenAlexW2739039423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.