Evidence map›Paper›PMID 28739781›Full record

ArticleAntimicrobial agents and chemotherapy2017

Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP0595.

Wanchun Jin, Jun-Ichi Wachino, Yoshihiro Yamaguchi, Kouji Kimura, Anupriya Kumar, Mototsugu Yamada, Akihiro Morinaka, Yoshiaki Sakamaki, Minoru Yonezawa, Hiromasa Kurosaki and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.Antimicrobial agents and chemotherapy · 2019
    Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Wanchun JinDepartment of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Jun-Ichi WachinoDepartment of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan wachino@med.nagoya-u.ac.jp.
Yoshihiro YamaguchiEnvironmental Safety Center, Kumamoto University, Kumamoto, Japan.
Kouji KimuraDepartment of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Anupriya KumarDepartment of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Mototsugu YamadaMeiji Seika Pharma Co., Ltd., Yokohama, Kanagawa, Japan.
Akihiro MorinakaMeiji Seika Pharma Co., Ltd., Yokohama, Kanagawa, Japan.
Yoshiaki SakamakiMeiji Seika Pharma Co., Ltd., Yokohama, Kanagawa, Japan.
Minoru YonezawaMeiji Seika Pharma Co., Ltd., Yokohama, Kanagawa, Japan.
Hiromasa KurosakiCollege of Pharmacy, Kinjo Gakuin University, Nagoya, Aichi, Japan.
Yoshichika ArakawaDepartment of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Nagoya University · JPKinjo Gakuin University · JPKumamoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of effective inhibitors that block extended-spectrum β-lactamases (ESBLs) and restore the action of β-lactams represents an effective strategy against ESBL-producing

Indexed as

Azabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamasesCatalytic DomainCephalosporinsCrystallography, X-RayEscherichia coliHumansLactamsMicrobial Sensitivity TestsavibactamAzabicyclo Compoundsbeta-Lactamase Inhibitorsbeta-LactamasesCephalosporinsLactamsnacubactamTLA-3 beta-lactamaseavibactamcrystal structurediazabicyclooctaneESBLextended-spectrum β-lactamaseOP0595TLA-3

Identifiers

PMID28739781
PMCPMC5610492
OpenAlexW2736364059

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.