Evidence map›Paper›PMID 28739678›Full record

ArticleThe Journal of cell biology2017

MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1.

Ann-Christin Hau, Britta Moyo Grebbin, Zsuzsa Agoston, Marie Anders-Maurer, Tamara Müller, Anja Groß, Jasmine Kolb, Julian D Langer, Claudia Döring, Dorothea Schulte

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. PARP1 and OGG1 in Medicated Patients With Depression and the Response to ECT.The international journal of neuropsychopharmacology · 2023
    Article
  5. NADOxidative medicine and cellular longevity · 2023
    Review
  6. Review
  7. Article
  8. The multifaceted role of PARP1 in RNA biogenesis.Wiley interdisciplinary reviews. RNA · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Oncogenic and tumor suppressor function of MEIS and associated factors.Turkish journal of biology = Turk biyoloji dergisi · 2020
    Article
  14. Article
  15. Novel insights into PARPs in gene expression: regulation of RNA metabolism.Cellular and molecular life sciences : CMLS · 2019
    Review
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ann-Christin HauInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.ORCID 0000-0002-4412-2355
Britta Moyo GrebbinInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.ORCID 0000-0002-7371-8924
Zsuzsa AgostonInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.
Marie Anders-MaurerInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.
Tamara MüllerInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.
Anja GroßInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.
Jasmine KolbInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.
Julian D LangerDepartment of Molecular Membrane Biology, Max Planck Institute for Biophysics, Frankfurt, Germany.
Claudia DöringSenckenberg Institute of Pathology, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany.
Dorothea SchulteInstitute of Neurology, Edinger Institute, University Hospital Frankfurt, J.W. Goethe University, Frankfurt, Germany dorothea.schulte@kgu.de.ORCID 0000-0002-7243-6319
Goethe University Frankfurt · DEMax Planck Institute of Biophysics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pre-B-cell leukemia homeobox (PBX) and myeloid ecotropic viral integration site (MEIS) proteins control cell fate decisions in many physiological and pathophysiological contexts, but how these proteins function mechanistically remains poorly defined. Focusing on the first hours of neuronal differentiation of adult subventricular zone-derived stem/progenitor cells, we describe a sequence of events by which PBX-MEIS facilitates chromatin accessibility of transcriptionally inactive genes: In undifferentiated cells, PBX1 is bound to the H1-compacted promoter/proximal enhancer of the neuron-specific gene

Indexed as

Cell LineageNeurogenesisAdult Stem CellsAnimalsBinding SitesCell Line, TumorChromatinChromatin Assembly and DisassemblyDoublecortin Domain ProteinsDoublecortin ProteinFemaleGene Expression Regulation, DevelopmentalHEK293 CellsHistonesHomeodomain ProteinsHumansChromatinDCX protein, humanDcx protein, mouseDoublecortin Domain ProteinsDoublecortin ProteinHistonesHomeodomain ProteinsMicrotubule-Associated ProteinsMrg1 protein, mouseNeuropeptidesParp1 protein, mousePbx1 protein, mousePoly (ADP-Ribose) Polymerase-1Pre-B-Cell Leukemia Transcription Factor 1Transcription Factors

Identifiers

PMID28739678
PMCPMC5584172
OpenAlexW2737806554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.