Evidence map›Paper›PMID 28739632›Full record

ReviewJournal of molecular endocrinology2017

Therapeutic potential of mesenchymal stem cells for diabetes.

Alvaro Moreira, Samuel Kahlenberg, Peter Hornsby

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of molecular endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Advancements in diabetes research and stem cell therapy: a concise review.Journal of diabetes and metabolic disorders · 2025
    Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alvaro MoreiraDepartment of PediatricsUniversity of Texas Health Science Center-San Antonio, San Antonio, Texas, USA moreiraa@uthscsa.edu.
Samuel KahlenbergDepartment of PediatricsUniversity of Texas Health Science Center-San Antonio, San Antonio, Texas, USA.
Peter HornsbyDepartment of PhysiologyTexas Research Park Campus, Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, USA.
The University of Texas Health Science Center at San Antonio · USKronos Longevity Research Institute · US

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthKL2TR001118 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, DOUGHERTY, DONALD M · 2013 to 2017
$3.4M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthKL2TR000118 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2012 to 2013
$757k
Institute for Integration of Medicine & Science: A Partnership to Improve HealthTL1TR001119 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, DOUGHERTY, DONALD M · 2013 to 2017
$640k
NCATS NIH HHS KL2 TR000118NCATS NIH HHS KL2 TR001118NCATS NIH HHS TL1 TR001119NCATS NIH HHS UL1 TR001120
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative effects, ease of isolation and low immunogenicity. Experimental and clinical studies have provided promising results using MSCs to treat diabetes. This review will summarize the role of MSCs on tissue repair, provide emerging strategies to improve MSC function and describe how these processes translate to clinical treatments for diabetes.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsCell- and Tissue-Based TherapyCell DifferentiationCell SeparationCell SurvivalDiabetes MellitusFetal BloodGenetic TherapyHumansMesenchymal Stem CellsPhenotypeRegenerationTransplantation, Homologousdiabetesendocrinemesenchymal stem celltissue regeneration

Identifiers

PMID28739632
PMCPMC5570611
OpenAlexW2736808007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.