Evidence map›Paper›PMID 28739594›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2017

Here, There, and Anywhere? Arguments for and against the Physical Plasma Cell Survival Niche.

Joel R Wilmore, David Allman

Open access · greenAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  6. Article
  7. Article
  8. Review
  9. Review
  10. Analysis of Normal Plasma Cell Distribution Across Distinct Age Cohorts Reveals Age-Dependent Changes.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Effects of invivo CXCR4 blockade and proteasome inhibition on bone marrow plasma cells in HLA-sensitized kidney transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joel R WilmoreDepartment of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
David AllmanDepartment of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 dallman@mail.med.upenn.edu.
University of Pennsylvania · US

Funding

Long-lived CD19-positive plasma cellsR01AI097590 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M · 2012 to 2016
$1.9M
Origins of serum IgA antibodiesR01AI113543 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M · 2014 to 2017
$1.6M
Mechanisms of systemic IgA induction by commensal bacteriaF32AI114089 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WILMORE, JOEL R · 2015 to 2016
$112k
NIAID NIH HHS F32 AI114089NIAID NIH HHS R01 AI097590NIAID NIH HHS R01 AI113543
6 · The paper itself

Abstract

To maintain Ab titers, individual plasma cells must survive for extended periods, perhaps even for the life of the host. Although it is clear that plasma cell survival requires cell extrinsic signals, the nature and source of these signals remains open for debate. It is commonly postulated that plasma cells only gain access to these signals within specialized regulatory microenvironments, or niches, in the bone marrow or in the gut. In this review we discuss current concepts and information surrounding plasma cell survival niches, and consider two opposing models to explain long-term serologic immunity.

Indexed as

Cell SurvivalCellular MicroenvironmentAnimalsBone MarrowBone Marrow CellsHumansMiceModels, BiologicalPlasma CellsSignal Transduction

Identifiers

PMID28739594
PMCPMC5651088
OpenAlexW2737828297

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.