Evidence map›Paper›PMID 28739578›Full record

ArticleEvidence-based mental health2017

Applying deep neural networks to unstructured text notes in electronic medical records for phenotyping youth depression.

Joseph Geraci, Pamela Wilansky, Vincenzo de Luca, Anvesh Roy, James L Kennedy, John Strauss

Open access · hybridAbstract read
In one paragraph

Article in Evidence-based mental health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Joseph GeraciCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
Pamela WilanskyCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
Vincenzo de LucaCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
Anvesh RoyCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
James L KennedyCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
John StraussCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
Centre for Addiction and Mental Health · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe report a study of machine learning applied to the phenotyping of psychiatric diagnosis for research recruitment in youth depression, conducted with 861 labelled electronic medical records (EMRs) documents. A model was built that could accurately identify individuals who were suitable candidates for a study on youth depression.

objectiveOur objective was a model to identify individuals who meet inclusion criteria as well as unsuitable patients who would require exclusion.

methodsOur methods included applying a system that coded the EMR documents by removing personally identifying information, using two psychiatrists who labelled a set of EMR documents (from which the 861 came), using a brute force search and training a deep neural network for this task.

findingsAccording to a cross-validation evaluation, we describe a model that had a specificity of 97% and a sensitivity of 45% and a second model with a specificity of 53% and a sensitivity of 89%. We combined these two models into a third one (sensitivity 93.5%; specificity 68%; positive predictive value (precision) 77%) to generate a list of most suitable candidates in support of research recruitment.

conclusionOur efforts are meant to demonstrate the potential for this type of approach for patient recruitment purposes but it should be noted that a larger sample size is required to build a truly reliable recommendation system. CLINICAL IMPLICATIONS: Future efforts will employ alternate neural network algorithms available and other machine learning methods.

Indexed as

AlgorithmsDepressionElectronic Health RecordsMachine LearningAdolescentHumansYoung Adultdeep learningdepressionneural networkphenotypingyouth

Identifiers

PMID28739578
PMCPMC5566092
OpenAlexW2738242267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.