ArticleMolecular pharmacology2017
Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor.
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Article in Molecular pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Mechanistic profiling and optimized production of Altenusin, a fungal carboxy-biphenyl scaffold for tyrosinase inhibition.RSC advances · 2026Article
- The peroxisome proliferator-activated receptor α/β/γ agonist NCPC-626 from microbial metabolites alleviates metabolic dysfunction-associated steatohepatitis in mice.Molecular pharmacology · 2025Article
- Non-Steroidal FXR Agonistic Dimeric 2-Methyl-4-(1-glycerol)furan with Lipid-Lowering Activities from Marine-DerivedMarine drugs · 2025Article
- Implication of Gut Mycobiome and Virome in Type-2 Diabetes Mellitus: Uncovering the Hidden Players.Phenomics (Cham, Switzerland) · 2025Review
- Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis.Aging and disease · 2024Review
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Article
- Natural resorcylic lactones derived from alternariol.Beilstein journal of organic chemistry · 2024Review
- Research Progress of Natural Products with the Activity of Anti-nonalcoholic Steatohepatitis.Mini reviews in medicinal chemistry · 2024Review
- Farnesoid X receptor regulators from natural products and their biological function.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- [Characteristics and research progress on the role of intestinal fungi in chronic liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease.Frontiers in pharmacology · 2022Review
- Improving glucose and lipids metabolism: drug development based on bile acid related targets.Cell stress · 2021Review
- Molecular mechanism underlying the hypolipidemic effect of Shanmei Capsule based on network pharmacology and molecular docking.Technology and health care : official journal of the European Society for Engineering and Medicine · 2021Article
- Natural Products Targeting Liver X Receptors or Farnesoid X Receptor.Frontiers in pharmacology · 2021Review
- The Role of Intestinal Fungi and Its Metabolites in Chronic Liver Diseases.Gut and liver · 2020Review
- The Molecular and Mechanistic Insights Based on Gut-Liver Axis: Nutritional Target for Non-Alcoholic Fatty Liver Disease (NAFLD) Improvement.International journal of molecular sciences · 2020Review
- Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis.Nutrition & metabolism · 2020Article
- Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury.The Journal of pharmacology and experimental therapeutics · 2019Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Zhihui ZhengCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Zanmei ZhaoCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Shuqiang LiCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Xinhua LuCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Mengxi JiangCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Jie LinCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Yunqi AnCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Yang XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Meishu XuCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Wenbin ShenCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Grace L GuoCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Yixian HuangCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Song LiCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Xuexia ZhangCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.).
Wen XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences (Zh.Z., Za.Z., M.J., Y.A., Y.X., M.X., Y.H., S.L., W.X.) and Department of Pharmacology and Chemical Biology (W.X.), University of Pittsburgh, Pittsburgh, Pennsylvania; New Drug Research and Development Center, North China Pharmaceutical Group, Shijiazhuang, Hebei, China (Zh.Z., X.L., J.L., W.S., X.Z.); Occupational Disease Department, Peking University Third Hospital, Beijing, China (Za.Z., S.L.); and Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey (G.L.G.) wex6@pitt.edu.
University of Pittsburgh · USPeking University Third Hospital · CNRutgers, The State University of New Jersey · USPeking University · CN
Funding
The Perinatal Pharmacology of the Nuclear ReceptorR01HD073070 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIE, WEN · 2013 to 2017
$1.6MNICHD NIH HHS R01 HD073070
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. The incidence of NAFLD has increased steadily due to its close association with the global epidemic of obesity and type 2 diabetes. However, there is no effective pharmacological therapy approved for NAFLD. Farnesoid X receptor (FXR), a member of the nuclear receptor subfamily, plays important roles in maintaining the homeostasis of bile acids, glucose, and lipids. FXR agonists have shown promise for the treatment of NAFLD. In this study, we report altenusin (2076A), a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC
Indexed as
AnimalsBiphenyl CompoundsDose-Response Relationship, DrugHEK293 CellsHepatocytesHumansMaleMiceMice, Inbred C57BLMice, KnockoutMolecular Docking SimulationNon-alcoholic Fatty Liver DiseaseProtein Structure, SecondaryReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearaltenusinBiphenyl CompoundsReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclear
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