Evidence map›Paper›PMID 28739285›Full record

ReviewThe Journal of allergy and clinical immunology2017

Promising approaches for the treatment and prevention of viral respiratory illnesses.

Nikolaos G Papadopoulos, Spyridon Megremis, Nikolaos A Kitsioulis, Olympia Vangelatou, Peter West, Paraskevi Xepapadaki

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Vaccines for the common cold.The Cochrane database of systematic reviews · 2022
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Lower respiratory tract infection in the community: associations between viral aetiology and illness course.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021
    Article
  14. Review
  15. Observational
  16. Review
  17. Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. Community-acquired Respiratory Viruses Are a Risk Factor for Chronic Lung Allograft Dysfunction.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nikolaos G PapadopoulosDivision of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Pediatric Clinic, National & Kapodistrian University of Athens, Athens, Greece. Electronic address: ngp@allergy.gr.
Spyridon MegremisDivision of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom.
Nikolaos A KitsioulisAllergy Department, 2nd Pediatric Clinic, National & Kapodistrian University of Athens, Athens, Greece.
Olympia VangelatouDepartment of Nutritional Physiology & Feeding, Agricultural University of Athens, Athens, Greece.
Peter WestDivision of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom.
Paraskevi XepapadakiAllergy Department, 2nd Pediatric Clinic, National & Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of Manchester · GBAgricultural University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral respiratory tract infections are the most common human ailments, leading to enormous health and economic burden. Hundreds of viral species and subtypes have been associated with these conditions, with influenza viruses, respiratory syncytial virus, and rhinoviruses being the most frequent and with the highest burden. When considering prevention or treatment of viral respiratory tract infections, potential targets include the causative pathogens themselves but also the immune response, disease transmission, or even just the symptoms. Strategies targeting all these aspects are developing concurrently, and several novel and promising approaches are emerging. In this perspective we overview the entire range of options and highlight some of the most promising approaches, including new antiviral agents, symptomatic or immunomodulatory drugs, the re-emergence of natural remedies, and vaccines and public health policies toward prevention. Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses.

Indexed as

ImmunotherapyAnimalsHumansMass VaccinationOrthomyxoviridaeRespiratory Syncytial VirusesRespiratory Tract InfectionsRhinovirusViral VaccinesVirus DiseasesViral Vaccinesantiviralbronchiolitiscommon coldInfluenzamonoclonalnatural productspublic healthrespiratory syncytial virusrhinovirusvaccine

Identifiers

PMID28739285
PMCPMC7112313
OpenAlexW2736777985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.