ArticleEnvironmental health : a global access science source2017
Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France.
Article in Environmental health : a global access science source, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cancer incidence in the vicinity of open landfills in Guadeloupe, French West Indies.BMC public health · 2025Article
- Article
- Cancer Incidence among Marines and Navy Personnel and Civilian Workers Exposed to Industrial Solvents in Drinking Water at US Marine Corps Base Camp Lejeune: A Cohort Study.Environmental health perspectives · 2024Article
- Evaluation of mortality among Marines, Navy personnel, and civilian workers exposed to contaminated drinking water at USMC base Camp Lejeune: a cohort study.Environmental health : a global access science source · 2024Article
- Occupational exposure to organic solvents and the risk of developing testicular germ cell tumors (TESTIS study): Effect of combined exposure assessment on risk estimation.Scandinavian journal of work, environment & health · 2024Article
- Gingiva squamous-cell carcinoma in a non-smoking patient with occupational exposure to solvent siphoning using mouth: case report and literature review.Frontiers in public health · 2024Review
- Occupational Risk Factors for Laryngeal Cancer in Tunisia: A Case Control Study.La Medicina del lavoro · 2023Article
- Factors Associated with Total Laryngectomy Utilization in Patients with cT4a Laryngeal Cancer.Cancers · 2023Article
- Occupational Etiology of Oropharyngeal Cancer: A Literature Review.International journal of environmental research and public health · 2023Review
- Parental occupational exposure to solvents and risk of developing testicular germ cell tumors among sons: a French nationwide case-control study (TESTIS study).Scandinavian journal of work, environment & health · 2023Article
- ESTIMATION AND INFERENCE FOR EXPOSURE EFFECTS WITH LATENCY IN THE COX PROPORTIONAL HAZARDS MODEL IN THE PRESENCE OF EXPOSURE MEASUREMENT ERROR.The annals of applied statistics · 2023Article
- The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach.Biomolecules · 2023Review
- Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art.Journal of clinical medicine · 2023Review
- Scoping Review of 5 Common Occupational Cancers and Their Related Exposures.Medical journal of the Islamic Republic of Iran · 2022Article
- Head and neck cancer risk factors in the French West Indies.BMC cancer · 2021Article
- Analysis of Race and Gender Disparities in Mortality Trends from Patients Diagnosed with Nasopharyngeal, Oropharyngeal and Hypopharyngeal Cancer from 2000 to 2017.International journal of general medicine · 2021Article
- Mortality from Selected Cancers among Brazilian Mechanics.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Biological monitoring of occupational exposure to dichloromethane by means of urinalysis for un-metabolized dichloromethane.Industrial health · 2020Article
- Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium.Journal of occupational and environmental medicine · 2019Article
- Systematic screening for occupations and occupational exposures in head and neck squamous cell carcinoma patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk.
methodsWe analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France). Occupational exposure to five chlorinated solvents (perchloroethylene [PCE], trichloroethylene [TCE], methylene chloride [MC], chloroform [CF], and carbon tetrachloride [CT]) was assessed through job-exposure matrices. Odds ratios (ORs) and confidence intervals (95% CI) were estimated by unconditional logistic regression, adjusted for age, tobacco smoking, alcohol consumption, asbestos exposure, and other potential confounders.
resultsWe observed no association between chlorinated solvent exposure and head and neck cancer risk, despite a non-significant increase in risk among subjects who had the highest cumulative level of exposure to PCE, (OR = 1.81; 95% CI = 0.68 to 4.82). In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to PCE (p for trend = 0.04). The OR was 3.86 (95% CI = 1.30 to 11.48) for those exposed to the highest levels of PCE. A non-significant elevated risk of hypopharyngeal cancer was also observed in subjects exposed to the highest levels of MC (OR = 2.36; 95% CI = 0.98 to 5.85).
conclusionOur findings provide evidence that high exposure to PCE increases the risk of laryngeal cancer, and suggest an association between exposure to MC and hypopharyngeal cancer. Exposure to other chlorinated solvents was not associated with the risk of head and neck cancer.
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