Evidence map›Paper›PMID 28738781›Full record

ArticleBMC cardiovascular disorders2017

The value of a new cardiac magnetic resonance imaging protocol in Myocardial Infarction with Non-obstructive Coronary Arteries (MINOCA) - a case-control study using historical controls from a previous study with similar inclusion criteria.

Per Tornvall, E B Brolin, K Caidahl, K Cederlund, O Collste, M Daniel, C Ekenbäck, J Jensen, S Y-Hassan, L Henareh and 9 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02318498 (Stockholm Myocardial Infarction With Normal Coronaries), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02318498 nacompletednot on this map

Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2

TypeinterventionalSponsorKarolinska InstitutetRan2014 to 2019Enrolled150ConditionsMyocardial InfarctionArmsCMR
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Guidelines for the management of myocardial infarction/injury with non-obstructive coronary arteries (MINOCA): a position paper from the Dutch ACS working group.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Per TornvallDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. per.tornvall@ki.se.ORCID 0000-0002-7529-1338
E B BrolinClinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
K CaidahlMolecular Medicine and Surgery, Karolinska Hospital, Stockholm, Sweden.
K CederlundClinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
O CollsteDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
M DanielDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
C EkenbäckClinical Sciences Danderyd Hospital, Karolinska Hospital, Stockholm, Sweden.
J JensenDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
S Y-HassanMedicine Huddinge, Karolinska Hospital, Stockholm, Sweden.
L HenarehMedicine Huddinge, Karolinska Hospital, Stockholm, Sweden.
C Hofman-BangClinical Sciences Danderyd Hospital, Karolinska Hospital, Stockholm, Sweden.
P LyngåDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
E MaretClinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
N SarkarMedicine Solna, Karolinska Hospital, Stockholm, Sweden.
J SpaakClinical Sciences Danderyd Hospital, Karolinska Hospital, Stockholm, Sweden.
M SundqvistDepartment of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
P SörenssonMedicine Solna, Karolinska Hospital, Stockholm, Sweden.
M UganderMolecular Medicine and Surgery, Karolinska Hospital, Stockholm, Sweden.
S AgewallInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Karolinska Institutet · SEKarolinska University Hospital · SEUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) is common with a prevalence of 6% of all patients fulfilling the diagnosis of myocardial infarction. MINOCA should be considered a working diagnosis. Cardiac Magnetic Resonance (CMR) imaging has recently been suggested to be of great value to determine the cause behind MINOCA. The objectives of this paper are to describe the rationale behind the second Stockholm Myocardial Infarction with Normal Coronaries (SMINC-2) study and to discuss the protocol for investigation of MINOCA patients in the light of the recently published position paper from the European Society of Cardiology.

methodsThe SMINC-2 study is an open non-randomised study using historical controls for comparison. The primary aim is to prove that MINOCA patients investigated with the latest CMR imaging technique can achieve a diagnosis in 70% of all cases entirely by imaging. By including 150 patients we will have >80% chance to prove that the diagnostic accuracy can be improved by 20 absolute % with a p-value of less than 0.05 when compared with CMR imaging in the SMINC-1 study. Furthermore, in addition to invasive coronary angiography, coronary arteries are evaluated by computed tomography angiography to investigate coronary causes and questionnaires are used to describe Quality-of-Life (QoL). By January 1st 2017, 75 patients have been included. DISCUSSION: Whether CMR imaging can provide a diagnosis to an adequate proportion of MINOCA patients is unknown. Well-defined inclusion and exclusion criteria will be used to compare a MINOCA cohort from the population with an appropriate control group. Positive results are likely to influence future guidelines of the management of MINOCA. Furthermore, the study will give mechanistic insights into MINOCA in particular in patients with "true" myocardial infarction and describe QoL in this vulnerable group of patients.

trial registrationClinical Trials NCT02318498 .

Indexed as

Magnetic Resonance Imaging, CineAdultAgedCase-Control StudiesClinical ProtocolsComputed Tomography AngiographyCoronary AngiographyCoronary VesselsFemaleHistorically Controlled StudyHumansMaleMiddle AgedMyocardial InfarctionPredictive Value of TestsQuality of LifeCardiac magnetic imagingMyocardial infarctionNon-obstructive coronaries

Identifiers

PMID28738781
PMCPMC5525301
OpenAlexW2737011013

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.