Evidence map›Paper›PMID 28738403›Full record

ArticleTransplantation2017

Developing Consensus-Based Priority Outcome Domains for Trials in Kidney Transplantation: A Multinational Delphi Survey With Patients, Caregivers, and Health Professionals.

Bénédicte Sautenet, Allison Tong, Karine E Manera, Jeremy R Chapman, Anthony N Warrens, David Rosenbloom, Germaine Wong, John Gill, Klemens Budde, Lionel Rostaing and 25 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06474273 (A Multicenter Randomized Controlled Trial to Treat Acute t Cell Mediated Rejection in Kidney and Kidney-pancreas Transplant Recipients), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06474273 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

A Multicenter Randomized Controlled Trial to Treat Acute t Cell Mediated Rejection in Kidney and Kidney-pancreas Transplant Recipients

TypeinterventionalSponsorUniversity of SydneyRan2026 to 2030Enrolled540ConditionsRejection, Transplant, Kidney, Rejection, Transplant, PancreasArmsMethylprednisolone, Prednisone
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Assessing Deceased-Donor Kidneys Through Posttransplant Survival Prediction Algorithms.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026
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  13. The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes.Transplant international : official journal of the European Society for Organ Transplantation · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors.

Bénédicte Sautenet1 Sydney School of Public Health, The University of Sydney, Sydney, Australia.2 Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Sydney, Australia.3 Faculté de Médecine, Université Francois Rabelais, Tours, France.4 Department of Nephrology and Clinical Immunology, Tours Hospital, Tours, France.5 INSERM, U1246, Tours, France.6 Centre for Transplant and Renal Research, Westmead Hospital, Sydney, Australia.7 School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.8 ESRD Network 18, Los Angeles, CA.9 Division of Nephrology, University of British Columbia, Vancouver, Canada.10 Department of Nephrology, Charité - Universitätsmedizin Berlin, Germany.11 Department of Nephrology, Dialysis and Organ Transplantation, Centre Hospitalier Universitaire, Rangueil, Toulouse, France.12 Transplant Unit, University of Edinburgh, Edinburgh, United Kingdom.13 Department of Medicine, The University of Chicago, Chicago, IL.14 Renal Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.15 Department of Surgery, University of Minnesota, Minneapolis, MN.16 Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford, United Kingdom.17 Department Community Health Sciences, University of Calgary, Calgary, Canada.18 Department of Nephrology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA.19 Department of Nephrology, Monash Health and Centre for Inflammatory Diseases, Department of Medicine, Monash University, Clayton, Victoria, Australia.20 Department of Medicine, Stanford University School of Medicine, Stanford, CA.21 Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.22 Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, Scotland, United Kingdom.23 Department of Internal Medicine, Division of Nephrology, University of Vienna, Austria.24 Jockey Club Nephrology and Urology Centre, Princess Margaret Hospital, Hong Kong.25 Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.26 Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.27 Centre for Evidence in Transplantation, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.28 Selzman Institute for Kidney Health, Section of Nephrology, Baylor College of Medicine, Houston, TX.29 ANZDATA Registry, South Australia Health and Medical Research Institute, Adelaide, Australia.30 Renal Medicine and Transplantation, Royal Prince Alfred Hospital, Sydney, Australia.
Allison Tong
Karine E Manera
Jeremy R Chapman
Anthony N Warrens
David Rosenbloom
Germaine Wong
John Gill
Klemens Budde
Lionel Rostaing
Lorna Marson
Michelle A Josephson
Peter P Reese
Timothy L Pruett
Camilla S Hanson
Donal O'Donoghue
Helen Tam-Tham
Jean-Michel Halimi
Jenny I Shen
John Kanellis
John D Scandling
Kirsten Howard
Martin Howell
Nick Cross
Nicole Evangelidis
Philip Masson
Rainer Oberbauer
Samuel Fung
Shilpa Jesudason
Simon Knight
Sreedhar Mandayam
Stephen P McDonald
Steve Chadban
Tasleem Rajan
Jonathan C Craig

Funding

TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007357 · NIDDK · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW · 1986 to 2022
$4.8M
Trajectories of Adherence to Cardiovascular Medications in Patients on DialysisK23DK103972 · NIDDK · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI SHEN, JENNY I · 2015 to 2019
$934k
NIDDK NIH HHS K23 DK103972NIDDK NIH HHS T32 DK007357
6 · The paper itself

Abstract

backgroundInconsistencies in outcome reporting and frequent omission of patient-centered outcomes can diminish the value of trials in treatment decision making. We identified critically important outcome domains in kidney transplantation based on the shared priorities of patients/caregivers and health professionals.

methodsIn a 3-round Delphi survey, patients/caregivers and health professionals rated the importance of outcome domains for trials in kidney transplantation on a 9-point Likert scale and provided comments. During rounds 2 and 3, participants rerated the outcomes after reviewing their own score, the distribution of the respondents' scores, and comments. We calculated the median, mean, and proportion rating 7 to 9 (critically important), and analyzed comments thematically.

resultsOne thousand eighteen participants (461 [45%] patients/caregivers and 557 [55%] health professionals) from 79 countries completed round 1, and 779 (77%) completed round 3. The top 8 outcomes that met the consensus criteria in round 3 (mean, ≥7.5; median, ≥8; proportion, >85%) in both groups were graft loss, graft function, chronic rejection, acute rejection, mortality, infection, cancer (excluding skin), and cardiovascular disease. Compared with health professionals, patients/caregivers gave higher priority to 6 outcomes (mean difference of 0.5 or more): skin cancer, surgical complications, cognition, blood pressure, depression, and ability to work. We identified 5 themes: capacity to control and inevitability, personal relevance, debilitating repercussions, gaining awareness of risks, and addressing knowledge gaps.

conclusionsGraft complications and severe comorbidities were critically important for both stakeholder groups. These stakeholder-prioritized outcomes will inform the core outcome set to improve the consistency and relevance of trials in kidney transplantation.

Indexed as

CaregiversClinical Trials as TopicConsensusHealth PersonnelKidney TransplantationOutcome Assessment, Health CareAdolescentAdultAgedConsensus Statements as TopicDelphi TechniqueHumansMiddle AgedSurveys and QuestionnairesYoung Adult

Identifiers

PMID28738403
PMCPMC5603314

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.